Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.36 |
| ▸ | ABAT | P80404 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9102503 | 0.80 | MAOA (0.46) | LMNAERN1ALDH1A1TDP1CYP2C9 | |
| SCHEMBL1515822 | 0.75 | KDM4E (0.57) | LMNAGAAKMT2AALDH1A1HPGD | |
| SCHEMBL5605402 | 0.74 | TTR (0.48) | TTRKMT2AERN1ALDH1A1TRIM24 | |
| SCHEMBL6062329 | 0.72 | TTR (0.64) | TTRLMNAGAAKMT2AALDH1A1 | |
| SCHEMBL6509216 | 0.71 | TTR (0.47) | TTRLMNAGAAKMT2AALDH1A1 | |
| SCHEMBL11795573 | 0.70 | TTR (0.81) | TTRLMNAGAAKMT2AALDH1A1 | |
| SCHEMBL29446607 | 0.70 | TTR (0.81) | TTRLMNAGAAKMT2AALDH1A1 | |
| SCHEMBL4945903 | 0.69 | TTR (0.69) | TTRLMNAGAAKMT2AERN1 | |
| SCHEMBL15445427 | 0.69 | TTR (0.69) | TTRLMNAGAAKMT2AALDH1A1 | |
| SCHEMBL7263488 | 0.69 | TTR (0.64) | TTRLMNAGAAKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5001123-A | 2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonists | MERCK & CO., INC. (US) | 1991-03-19 | — | — | US | disclosed |