Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 8/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | HRH2 | P25021 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22130572 | 0.87 | HRH1 (0.36) | HRH1KCNH2 | |
| SCHEMBL17001812 | 0.87 | HRH1 (0.37) | HRH1KCNH2 | |
| SCHEMBL9762594 | 0.84 | KCNH2 (0.55) | HRH1KCNH2HTR2A | |
| SCHEMBL9761678 | 0.84 | KCNH2 (0.55) | HRH1KCNH2HTR2A | |
| SCHEMBL9762662 | 0.84 | KCNH2 (0.55) | HRH1KCNH2HTR2A | |
| SCHEMBL20320078 | 0.77 | CARM1 (0.39) | KCNH2 | |
| SCHEMBL17001796 | 0.74 | KCNH2 (0.34) | KCNH2ADORA2B | |
| SCHEMBL10446087 | 0.74 | HRH4 (0.37) | — | |
| SCHEMBL17001797 | 0.73 | SMN1; SMN2 (0.38) | KCNH2 | |
| SCHEMBL9762424 | 0.72 | AVPR1A (0.47) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5071855-A | Antihistamines, antiallergens | DOMPE FARMACEUTICI SPA (IT) | 1991-12-10 | — | — | US | claimed |
| US-5071855-A | Antihistamines, antiallergens | DOMPE FARMACEUTICI SPA (IT) | 1991-12-10 | — | — | US | disclosed |
| EP-0397614-A2 | Pharmacologically active piperdinylimidazopyridines | DOMPE' FARMACEUTICI S.p.A. (IT) | 1990-11-14 | — | — | EP | disclosed |