Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.55 |
| ▸ | HRH1 | P35367 | 7/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.39 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | LSS | P48449 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9761678 | 1.00 | KCNH2 (0.55) | KCNH2HRH1CHRM1PDK1PDK2 | |
| SCHEMBL9762594 | 1.00 | KCNH2 (0.55) | KCNH2HRH1CHRM1PDK1PDK2 | |
| SCHEMBL9761867 | 0.84 | HRH1 (0.42) | KCNH2HRH1HTR2A | |
| SCHEMBL9762432 | 0.75 | KCNH2 (0.49) | KCNH2HRH1CHRM1CYP2D6LSS | |
| SCHEMBL9761690 | 0.75 | KCNH2 (0.49) | KCNH2HRH1CHRM1CYP2D6LSS | |
| SCHEMBL9761330 | 0.75 | KCNH2 (0.49) | KCNH2HRH1CHRM1CYP2D6LSS | |
| SCHEMBL22130572 | 0.72 | HRH1 (0.36) | KCNH2HRH1 | |
| SCHEMBL17001812 | 0.72 | HRH1 (0.37) | KCNH2HRH1PDK1PDK2PDK3 | |
| SCHEMBL25724487 | 0.69 | ALDH1A1 (0.38) | — | |
| SCHEMBL10446087 | 0.68 | HRH4 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5071855-A | Antihistamines, antiallergens | DOMPE FARMACEUTICI SPA (IT) | 1991-12-10 | — | — | US | disclosed |
| EP-0397614-A2 | Pharmacologically active piperdinylimidazopyridines | DOMPE' FARMACEUTICI S.p.A. (IT) | 1990-11-14 | — | — | EP | disclosed |