Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 4/20 | 0.34 |
| ▸ | CA1 | P00915 | 4/20 | 0.34 |
| ▸ | CA2 | P00918 | 4/20 | 0.34 |
| ▸ | CA9 | Q16790 | 4/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TYMP | P19971 | 3/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MITF | O75030 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6275195 | 0.83 | LMNA (0.41) | KMT2ALMNATHRBCYP2C19CA12 | |
| SCHEMBL15570179 | 0.80 | CA1 (0.42) | KMT2ALMNATHRBCYP2C19CA12 | |
| SCHEMBL10400098 | 0.80 | KMT2A (0.45) | KMT2ALMNATHRBCYP2C19CA12 | |
| SCHEMBL28818918 | 0.76 | KMT2A (0.48) | KMT2ALMNATHRBCYP2C19CA12 | |
| Misonidazole SCHEMBL51943 | 0.75 | KMT2A (0.66) | KMT2ALMNATHRBCYP2C19CA12 | |
| SCHEMBL2360743 | 0.72 | KMT2A (0.43) | KMT2ALMNATHRBCYP2C19CA12 | |
| SCHEMBL296106 | 0.71 | LMNA (0.48) | KMT2ALMNATHRBCYP2C19CA12 | |
| SCHEMBL27795012 | 0.71 | KMT2A (0.44) | KMT2ALMNATHRBCYP2C19CA12 | |
| SCHEMBL9060085 | 0.69 | KMT2A (0.43) | KMT2ALMNATHRBCYP2C19CA12 | |
| SCHEMBL6275185 | 0.69 | KMT2A (0.55) | KMT2ALMNATHRBCYP2C19CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4921963-A | Platinum complexes with one radiosensitizing ligand | BRITISH COLUMBIA CANCER FOUNDATION (CA) | 1990-05-01 | — | — | US | claimed |
| US-7608612-B2 | Radiosensitizer formulations and methods for use | Matthews, Richard H. (US) | 2009-10-27 | — | — | US | disclosed |
| US-5026694-A | Antitumor agents | THE BRITISH COLUMBIA CANCER FOUNDATION (CA) | 1991-06-25 | — | — | US | disclosed |
| US-4921963-A | Platinum complexes with one radiosensitizing ligand | BRITISH COLUMBIA CANCER FOUNDATION (CA) | 1990-05-01 | — | — | US | disclosed |
| EP-0287317-A2 | Platinum complexes with one radiosensitizing ligand | THE BRITISH COLUMBIA CANCER FOUNDATION (CA) | 1988-10-19 | — | — | EP | disclosed |