Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1312040 | 0.98 | TSHR (0.47) | TSHRKCNH2EPHX1KCNJ1SIRT2 | |
| SCHEMBL1310286 | 0.92 | KCNH2 (0.51) | TSHRKCNH2EPHX1KCNJ1SIRT2 | |
| SCHEMBL10346573 | 0.92 | TSHR (0.60) | TSHRKCNH2EPHX1KCNJ1SIRT2 | |
| SCHEMBL3656180 | 0.87 | TSHR (0.62) | TSHRKCNH2KCNJ1IDO1LOXL2 | |
| SCHEMBL9165352 | 0.83 | TSHR (0.55) | TSHRKCNH2EPHX1KCNJ1IDO1 | |
| SCHEMBL11308396 | 0.83 | TSHR (0.55) | TSHRKCNH2EPHX1KCNJ1IDO1 | |
| SCHEMBL8727026 | 0.83 | TSHR (0.55) | TSHRKCNH2EPHX1KCNJ1IDO1 | |
| SCHEMBL1312325 | 0.83 | TSHR (0.58) | TSHRKCNH2KCNJ1SIRT2IDO1 | |
| SCHEMBL378396 | 0.83 | TSHR (0.58) | TSHRKCNH2EPHX1KCNJ1IDO1 | |
| SCHEMBL7943874 | 0.82 | KCNH2 (0.59) | TSHRKCNH2KCNJ1SIRT2IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4990505-A | Treating asthma, bronchitis; adrenergic stimulants | GLAXO GROUP LIMITED (GB) | 1991-02-05 | — | — | US | disclosed |