Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 known ✓ | Q12809 | 8/20 | 0.62 |
| ▸ | HRH1 known ✓ | P35367 | 12/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.46 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9762713 | 1.00 | KCNH2 (0.62) | KCNH2HRH1CHRM1CYP2D6SLC6A9 | |
| Fumaric Acid SCHEMBL9634650 | 0.78 | SLC6A9 (0.51) | KCNH2CHRM1SLC6A9MAPTNPSR1 | |
| Fumaric Acid SCHEMBL9634773 | 0.77 | SLC6A9 (0.58) | CHRM1SLC6A9NPSR1 | |
| Fumaric Acid SCHEMBL9635958 | 0.76 | SLC6A9 (0.62) | CHRM1SLC6A9MAPTNPSR1 | |
| Fumaric Acid SCHEMBL10383261 | 0.76 | SLC6A9 (0.45) | SLC6A9MAPT | |
| Fumaric Acid SCHEMBL9634684 | 0.76 | SLC6A9 (0.57) | HRH1CHRM1SLC6A9MAPTNPSR1 | |
| Fumaric Acid SCHEMBL10382780 | 0.76 | SLC6A9 (0.49) | HRH1SLC6A9MAPT | |
| Fumaric Acid SCHEMBL9634735 | 0.75 | SLC6A9 (0.58) | KCNH2CHRM1SLC6A9MAPTNPSR1 | |
| Fumaric Acid SCHEMBL9634676 | 0.75 | SLC6A9 (0.56) | CHRM1SLC6A9 | |
| Fumaric Acid SCHEMBL10382810 | 0.75 | MAPT (0.41) | HRH1SLC6A9MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5071855-A | Antihistamines, antiallergens | DOMPE FARMACEUTICI SPA (IT) | 1991-12-10 | — | — | US | disclosed |