Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 19/20 | 0.43 |
| ▸ | ADRB1 known ✓ | P08588 | 18/20 | 0.43 |
| ▸ | ADRB3 known ✓ | P13945 | 18/20 | 0.43 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.39 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.39 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.39 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.39 |
| ▸ | HTR1D known ✓ | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B known ✓ | P28222 | 1/20 | 0.39 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.39 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.39 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9762641 | 0.91 | CCR5 (0.41) | ADRB2ADRB1ADRB3KDM4EMEN1 | |
| SCHEMBL9763053 | 0.88 | ADRB2 (0.41) | ADRB2ADRB1ADRB3KDM4EMEN1 | |
| SCHEMBL9763349 | 0.87 | ADRB2 (0.44) | ADRB2ADRB1ADRB3KDM4EMEN1 | |
| SCHEMBL9763274 | 0.86 | ADRB2 (0.39) | ADRB2ADRB1ADRB3KDM4EMEN1 | |
| SCHEMBL9763316 | 0.84 | ADRB2 (0.47) | ADRB2ADRB1ADRB3 | |
| SCHEMBL9763301 | 0.84 | ADRB2 (0.37) | ADRB2ADRB1ADRB3KDM4EMEN1 | |
| SCHEMBL9763623 | 0.83 | AR (0.38) | ADRB2ADRB1ADRB3KDM4EMEN1 | |
| SCHEMBL9762754 | 0.83 | LIMK2 (0.44) | ADRB2ADRB1ADRB3KDM4EMEN1 | |
| SCHEMBL9763673 | 0.82 | ADRB2 (0.40) | ADRB2ADRB1ADRB3KDM4EMEN1 | |
| SCHEMBL10592068 | 0.80 | MAOB (0.40) | ADRB2ADRB1ADRB3KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4990505-A | Treating asthma, bronchitis; adrenergic stimulants | GLAXO GROUP LIMITED (GB) | 1991-02-05 | — | — | US | disclosed |