Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.37 |
| ▸ | PMM2 | O15305 | 1/20 | 0.37 |
| ▸ | MPI | P34949 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PHOSPHO1 | Q8TCT1 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9763456 | 0.87 | KDM4E (0.44) | KDM4EALDH1A1TDP1L3MBTL1METAP2 | |
| Bromide SCHEMBL9763504 | 0.82 | KDM4E (0.41) | KDM4EALDH1A1TDP1L3MBTL1METAP2 | |
| SCHEMBL2676351 | 0.76 | KDM4E (0.48) | KDM4EALDH1A1TDP1L3MBTL1METAP2 | |
| SCHEMBL9764173 | 0.76 | KDM4E (0.50) | KDM4EALDH1A1TDP1L3MBTL1METAP2 | |
| SCHEMBL9764267 | 0.75 | KDM4E (0.46) | KDM4EALDH1A1TDP1L3MBTL1METAP2 | |
| SCHEMBL9763582 | 0.73 | HMGCR (0.49) | — | |
| SCHEMBL1717723 | 0.70 | TACR3 (0.50) | KDM4EALDH1A1LMNAHSD17B10 | |
| SCHEMBL9335250 | 0.70 | USP14 (0.38) | KDM4EALDH1A1TDP1L3MBTL1 | |
| SCHEMBL9763589 | 0.68 | MAPK14 (0.43) | KDM4EALDH1A1LMNAPTGS2 | |
| SCHEMBL9764024 | 0.67 | HMGCR (0.60) | KDM4EALDH1A1LMNAPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5004747-A | Isoquinolinones | MAY & BAKER LIMITED (GB) | 1991-04-02 | — | — | US | disclosed |
| EP-0326386-A2 | Isoquinolinones | MAY & BAKER LIMITED (GB) | 1989-08-02 | — | — | EP | disclosed |