Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 known ✓ | P21728 | 16/20 | 0.67 |
| ▸ | DRD2 known ✓ | P14416 | 4/20 | 0.67 |
| ▸ | MTOR known ✓ | P42345 | 1/20 | 0.59 |
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.56 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.56 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.56 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.56 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.56 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.56 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.56 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.56 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.56 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.56 |
| ▸ | DRD5 | P21918 | 4/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.59 |
| ▸ | THPO | P40225 | 2/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.59 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9764163 | 1.00 | DRD1 (0.67) | DRD1DRD2DRD5HSD17B10MAPK1 | |
| SCHEMBL9764281 | 0.91 | DRD1 (0.75) | DRD1DRD2DRD5HSD17B10MAPK1 | |
| Trepipam SCHEMBL29401068 | 0.81 | CYP2D6 (0.82) | DRD1DRD2DRD5HSD17B10MAPK1 | |
| SCHEMBL16263409 | 0.81 | DRD1 (0.72) | DRD1DRD2DRD5HSD17B10MAPK1 | |
| Sch-23390 SCHEMBL461649 | 0.80 | DRD1 (1.00) | DRD1DRD2DRD5HSD17B10MAPK1 | |
| Sch-23390 SCHEMBL7616573 | 0.80 | DRD1 (1.00) | DRD1DRD2DRD5HSD17B10MAPK1 | |
| Sch-23390 SCHEMBL7616595 | 0.80 | DRD1 (1.00) | DRD1DRD2DRD5HSD17B10MAPK1 | |
| Sch-23390 SCHEMBL9879320 | 0.80 | DRD1 (1.00) | DRD1DRD2DRD5HSD17B10MAPK1 | |
| Sch-23390 SCHEMBL11566592 | 0.80 | DRD1 (1.00) | DRD1DRD2DRD5HSD17B10MAPK1 | |
| Sch-23390 SCHEMBL11566584 | 0.80 | DRD1 (1.00) | DRD1DRD2DRD5HSD17B10MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4996202-A | 1,2,4,5 tetrahydro benzazepine-3 compounds and antipsychotic use thereof | SCHERING CORPORATION (US) | 1991-02-26 | — | — | US | disclosed |