Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 8/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.37 |
| ▸ | GMNN | O75496 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CETP | P11597 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | UBE2N | P61088 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9764661 | 1.00 | GPR84 (0.41) | GPR84FFAR1FFAR4CYP2D6SPHK1 | |
| SCHEMBL4612273 | 0.77 | GPR84 (0.44) | GPR84FFAR1FFAR4CYP2D6SPHK1 | |
| SCHEMBL9407885 | 0.77 | GPR84 (0.44) | GPR84FFAR1FFAR4CYP2D6SPHK1 | |
| SCHEMBL11405127 | 0.75 | GPR84 (0.43) | GPR84FFAR1FFAR4SPHK1PSMD14 | |
| SCHEMBL4623887 | 0.74 | TSHR (0.44) | TSHR | |
| SCHEMBL9200158 | 0.74 | FFAR1 (0.52) | GPR84FFAR1FFAR4SPHK1LMNA | |
| SCHEMBL7065643 | 0.74 | FFAR1 (0.52) | GPR84FFAR1FFAR4SPHK1LMNA | |
| SCHEMBL910534 | 0.74 | FFAR1 (0.52) | GPR84FFAR1FFAR4SPHK1LMNA | |
| SCHEMBL9334962 | 0.74 | FFAR1 (0.52) | GPR84FFAR1FFAR4SPHK1LMNA | |
| SCHEMBL16074765 | 0.74 | GPR84 (0.48) | GPR84FFAR1FFAR4CYP2D6SPHK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5041694-A | Substituted glutaric acid lactones in the treatment of hyperlipidemia | G. D. SEARLE & CO. (US) | 1991-08-20 | — | — | US | disclosed |
| US-4965373-A | Substituted glutaric acid lactones in the treatment of hyperlipidemia | G. D. SEARLE & CO. (US) | 1990-10-23 | — | — | US | disclosed |
| US-4895973-A | Substituted glutaric acid lactones in the treatment of hyperlipidemia | G. D. SEARLE & COMPANY (US) | 1990-01-23 | — | — | US | disclosed |
| EP-0194610-B1 | SUBSTITUTED GLUTARIC ACID LACTONES IN THE TREATMENT OF HYPERLIPIDEMIA | G.D. Searle & Co. (US) | 1989-02-22 | — | — | EP | disclosed |
| US-4622338-A | Substituted glutaric acid lactones in the treatment of hyperlipidemia | G. D. SEARLE & CO. (US) | 1986-11-11 | — | — | US | disclosed |
| EP-0194610-A1 | Substituted glutaric acid lactones in the treatment of hyperlipidemia | G.D. Searle & Co. (US) | 1986-09-17 | — | — | EP | disclosed |