Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | APEX1 | P27695 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | TNF | P01375 | 1/20 | 0.46 |
| ▸ | SNCA | P37840 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10349181 | 0.87 | MCHR1 (0.57) | MEN1LMNAKMT2ATRPV1HPGD | |
| SCHEMBL10928865 | 0.87 | MCHR1 (0.57) | POLBHPGDTNFMCHR1HTR2C | |
| SCHEMBL5388983 | 0.87 | TRPV1 (0.55) | LMNAPKMTRPV1MCHR1HTR2C | |
| SCHEMBL9764719 | 0.86 | TRPV1 (0.56) | PKMTRPV1MCHR1MAPT | |
| SCHEMBL10929115 | 0.85 | HIF1A (0.56) | MEN1LMNAKMT2ATRPV1CYP2C9 | |
| SCHEMBL10930726 | 0.84 | MCHR1 (0.59) | MEN1LMNAPOLBPKMKMT2A | |
| SCHEMBL10931197 | 0.83 | MEN1 (0.55) | MEN1LMNAPOLBKMT2ATDP1 | |
| SCHEMBL10929906 | 0.79 | RAB9A (0.58) | MEN1KMT2ATRPV1HPGDALDH1A1 | |
| SCHEMBL10930580 | 0.79 | KCNK3 (0.53) | MEN1LMNAPOLBPKMKMT2A | |
| SCHEMBL9764698 | 0.79 | TRPV1 (0.60) | LMNAPOLBKMT2ATRPV1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0113778-B1 | ARYL SUBSTITUTED AMINOMETHYL BENZENE DERIVATIVES USEFUL AS ANTIARRHYTHMIC AGENTS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1990-05-09 | — | — | EP | claimed |
| US-5059620-A | Antiarrhythmia agents | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1991-10-22 | — | — | US | disclosed |
| EP-0113778-B1 | ARYL SUBSTITUTED AMINOMETHYL BENZENE DERIVATIVES USEFUL AS ANTIARRHYTHMIC AGENTS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1990-05-09 | — | — | EP | disclosed |
| US-4923873-A | ANTIARRHYTHMIA AGENTS; SIDE EFFECT REDUCTION | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1990-05-08 | — | — | US | disclosed |
| US-4755527-A | Aryl substituted aminomethyl benzene derivatives | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1988-07-05 | — | — | US | disclosed |
| US-4748184-A | Aryl substituted aminomethyl benzene derivatives having antiarrhythmic utility | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1988-05-31 | — | — | US | disclosed |
| US-4562201-A | ANTIARRHYTHMIA AGNETS | AMERICAN HOSPITAL SUPPLY CORPORATION (US) | 1985-12-31 | — | — | US | disclosed |
| EP-0113778-A4 | ARYL SUBSTITUTED AMINOMETHYL BENZENE DERIVATIVES USEFUL AS ANTIARRHYTHMIC AGENTS. | AMERICAN HOSPITAL SUPPLY CORP (US) | 1985-06-06 | — | — | EP | disclosed |
| EP-0113778-A1 | ARYL SUBSTITUTED AMINOMETHYL BENZENE DERIVATIVES USEFUL AS ANTIARRHYTHMIC AGENTS. | AMERICAN HOSPITAL SUPPLY CORP (US) | 1984-07-25 | — | — | EP | disclosed |
| WO-1984000545-A1 | ARYL SUBSTITUTED AMINOMETHYL BENZENE DERIVATIVES USEFUL AS ANTIARRHYTHMIC AGENTS | AMERICAN HOSPITAL SUPPLY CORP (US) | 1984-02-16 | — | — | WO | disclosed |