Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 18/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | PTGES | O14684 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.43 |
| ▸ | LOX | P28300 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10556067 | 0.83 | ALOX5 (0.45) | ALOX5CYP1A2PTGESLMNALTA4H | |
| SCHEMBL10559910 | 0.82 | ALOX5 (0.59) | ALOX5CYP1A2PTGESLMNALTA4H | |
| Potassium SCHEMBL10559851 | 0.81 | ALOX5 (0.57) | ALOX5CYP1A2PTGESLMNALTA4H | |
| SCHEMBL10611208 | 0.81 | ALOX5 (0.57) | ALOX5CYP1A2PTGESLMNALTA4H | |
| SCHEMBL10561140 | 0.76 | ALOX5 (0.53) | ALOX5CYP1A2PTGESLMNALTA4H | |
| SCHEMBL10559599 | 0.75 | ALOX5 (0.59) | ALOX5CYP1A2PTGESLMNALTA4H | |
| SCHEMBL10561270 | 0.74 | ALOX5 (0.47) | ALOX5EPHX2 | |
| SCHEMBL9764883 | 0.74 | ALOX5 (0.39) | ALOX5LTB4R | |
| SCHEMBL10560605 | 0.71 | ALOX5 (0.44) | ALOX5CYP1A2PTGESLMNALTA4H | |
| SCHEMBL9475050 | 0.71 | ALOX5 (0.80) | ALOX5PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0422079-A4 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | — | 1991-08-21 | — | — | EP | disclosed |
| EP-0422079-A1 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | ABBOTT LABORATORIES (US) | 1991-04-17 | — | — | EP | disclosed |
| WO-1989012636-A1 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | ABBOTT LABORATORIES (US) | 1989-12-28 | — | — | WO | disclosed |
| EP-0346939-A1 | Tricyclic lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1989-12-20 | — | — | EP | disclosed |
| US-4822811-A | Carbazole lipoxygenase inhibiting compounds, compositions and use | ABBOTT LABORATORIES (US) | 1989-04-18 | — | — | US | disclosed |
| US-4769387-A | Dibenzofuran lipoxygenase inhibiting compounds, compositions and use | ABBOTT LABORATORIES (US) | 1988-09-06 | — | — | US | disclosed |