Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.39 |
| ▸ | F9 | P00740 | 1/20 | 0.37 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.36 |
| ▸ | LTB4R | Q15722 | 4/20 | 0.35 |
| ▸ | LTB4R2 | Q9NPC1 | 4/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.35 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.33 |
| ▸ | PLK4 | O00444 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9764825 | 0.83 | SLC9A1 (0.33) | ALOX5SLC9A1DYRK1A | |
| SCHEMBL9764833 | 0.82 | ALOX5 (0.43) | ALOX5LTB4RLIMK1NPC1HPGD | |
| SCHEMBL9764852 | 0.79 | PLA2G10 (0.40) | ALOX5PLA2G10PLA2G2ASLCO1B1 | |
| SCHEMBL10559630 | 0.76 | ALOX5 (0.42) | ALOX5LIMK1NPC1HPGDRAB9A | |
| SCHEMBL9764866 | 0.75 | ALOX5 (0.43) | ALOX5LIMK1NPC1HPGDRAB9A | |
| SCHEMBL9764851 | 0.74 | ALOX5 (0.48) | ALOX5LTB4R | |
| SCHEMBL9764814 | 0.73 | ALOX5 (0.45) | ALOX5SLC9A1MCL1PARP14LIMK1 | |
| SCHEMBL22137041 | 0.70 | ALDH1A1 (0.57) | ALOX5F9PARP14LIMK1CSF1R | |
| SCHEMBL18457799 | 0.70 | ALOX5 (0.49) | ALOX5F9MCL1PARP14LIMK1 | |
| Ammonia Solution, Strong SCHEMBL9764837 | 0.69 | ALDH1A1 (0.39) | ALOX5NPC1HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0422079-A4 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | — | 1991-08-21 | — | — | EP | disclosed |
| EP-0422079-A1 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | ABBOTT LABORATORIES (US) | 1991-04-17 | — | — | EP | disclosed |
| WO-1989012636-A1 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | ABBOTT LABORATORIES (US) | 1989-12-28 | — | — | WO | disclosed |
| US-4822811-A | Carbazole lipoxygenase inhibiting compounds, compositions and use | ABBOTT LABORATORIES (US) | 1989-04-18 | — | — | US | disclosed |