Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 2/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.33 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.33 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.33 |
| ▸ | ITGAL | P20701 | 1/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10759336 | 0.77 | CHRNB4 (0.46) | CHRNB4CHRNA3CHRNB2CHRNA4CHRM2 | |
| SCHEMBL10975272 | 0.77 | CHRNB4 (0.46) | CHRNB4CHRNA3CHRNB2CHRNA4CHRM2 | |
| SCHEMBL10975275 | 0.77 | CHRNB4 (0.46) | CHRNB4CHRNA3CHRNB2CHRNA4CHRM2 | |
| SCHEMBL10977324 | 0.74 | CHRNB4 (0.40) | CHRNB4CHRNA3CHRNB2CHRNA4CHRM2 | |
| SCHEMBL10977318 | 0.74 | CHRNB4 (0.40) | CHRNB4CHRNA3CHRNB2CHRNA4CHRM2 | |
| SCHEMBL10977321 | 0.74 | CHRNB4 (0.40) | CHRNB4CHRNA3CHRNB2CHRNA4CHRM2 | |
| SCHEMBL10979584 | 0.72 | KMT2A (0.43) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL10979581 | 0.72 | KMT2A (0.43) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL19295487 | 0.72 | ABCG2 (0.41) | CHRNB4CHRNA3CHRNB2CHRNA4ABCG2 | |
| SCHEMBL9963162 | 0.70 | CHRNB4 (0.41) | CHRNB4CHRNA3CHRNB2CHRNA4CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0407016-A2 | Use of benzodioxinopyrrole derivatives in the manufacture of a medicament for the treatment of anxiety | GLAXO GROUP LIMITED (GB) | 1991-01-09 | — | — | EP | disclosed |
| EP-0371793-A3 | Use of a benzodioxinopyrrole derivatives for the preparation of a medicament in the treatment of cerebral ischaemia | GLAXO GROUP LIMITED (GB) | 1990-10-24 | — | — | EP | disclosed |
| EP-0371793-A2 | Use of a benzodioxinopyrrole derivatives for the preparation of a medicament in the treatment of cerebral ischaemia | GLAXO GROUP LIMITED (GB) | 1990-06-06 | — | — | EP | disclosed |