Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.41 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.41 |
| ▸ | ITGAL | P20701 | 1/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29309863 | 0.78 | CHRNB4 (0.46) | ABCG2ITGB2ICAM1ITGALCHRNB4 | |
| SCHEMBL10371016 | 0.76 | CHRNB4 (0.39) | ABCG2ITGB2ICAM1ITGALCHRNB4 | |
| SCHEMBL10371018 | 0.76 | CHRNB4 (0.39) | ABCG2ITGB2ICAM1ITGALCHRNB4 | |
| SCHEMBL10371015 | 0.76 | CHRNB4 (0.39) | ABCG2ITGB2ICAM1ITGALCHRNB4 | |
| Hydrochloric Acid SCHEMBL10977838 | 0.74 | CHRNB4 (0.38) | ABCG2ITGB2ICAM1ITGALCHRNB4 | |
| SCHEMBL20406703 | 0.73 | MAP3K14 (0.37) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL17974163 | 0.72 | ESR1 (0.40) | ABCG2ITGB2ICAM1ITGALNISCH | |
| SCHEMBL10975272 | 0.72 | CHRNB4 (0.46) | CHRNB4CHRNA3CHRNB2CHRNA4NISCH | |
| SCHEMBL9765075 | 0.72 | CHRNB4 (0.39) | ABCG2ITGB2ICAM1ITGALCHRNB4 | |
| SCHEMBL10975275 | 0.72 | CHRNB4 (0.46) | CHRNB4CHRNA3CHRNB2CHRNA4NISCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920075-B2 | Triazolopyridine and triazolopyrimidine inhibitors of myeloperoxidase | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-03-20 | — | — | US | disclosed |
| US-20170247396-A1 | TRIAZOLOPYRIDINE AND TRIAZOLOPYRIMIDINE INHIBITORS OF MYELOPEROXIDASE | BRISTOL MYERS SQUIBB CO (US) | 2017-08-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170247396-A1 | TRIAZOLOPYRIDINE AND TRIAZOLOPYRIMIDINE INHIBITORS OF MYELOPEROXIDASE | EPX, MPO, SERPINB1 | ABCG2 1747/4885ITGB2 2752/4885ICAM1 1825/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.