Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 2/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10977318 | 1.00 | CHRNB4 (0.40) | CHRNB4CHRNA3CHRNB2CHRNA4CHRM2 | |
| SCHEMBL10977324 | 1.00 | CHRNB4 (0.40) | CHRNB4CHRNA3CHRNB2CHRNA4CHRM2 | |
| SCHEMBL10975275 | 0.74 | CHRNB4 (0.46) | CHRNB4CHRNA3CHRNB2CHRNA4CHRM2 | |
| SCHEMBL10975272 | 0.74 | CHRNB4 (0.46) | CHRNB4CHRNA3CHRNB2CHRNA4CHRM2 | |
| SCHEMBL9765075 | 0.74 | CHRNB4 (0.39) | CHRNB4CHRNA3CHRNB2CHRNA4CHRM2 | |
| SCHEMBL10759336 | 0.74 | CHRNB4 (0.46) | CHRNB4CHRNA3CHRNB2CHRNA4CHRM2 | |
| SCHEMBL10979581 | 0.73 | KMT2A (0.43) | CHRNB4CHRNA3CHRNB2CHRNA4KMT2A | |
| SCHEMBL10979584 | 0.73 | KMT2A (0.43) | CHRNB4CHRNA3CHRNB2CHRNA4KMT2A | |
| SCHEMBL171335 | 0.71 | CHRNB4 (0.47) | CHRNB4CHRNA3CHRNB2CHRNA4CHRM2 | |
| SCHEMBL10977385 | 0.71 | OPRM1 (0.47) | CHRNB4CHRNA3CHRNB2CHRNA4CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4496579-A | AMINATION WITH AMMONIA OR PRIMARY AMINE; ANTIDEPRESANT | GLAXO GROUP LIMITED (GB) | 1985-01-29 | — | — | US | disclosed |