Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 13/20 | 0.57 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9223431 | 0.84 | KDM4E (0.50) | HPGDPOLBKDM4E | |
| SCHEMBL9537152 | 0.82 | MAPT (0.42) | HPGDPOLBKDM4E | |
| SCHEMBL9537985 | 0.80 | HPGD (0.57) | HPGDPTPN1POLBMAOAMAOB | |
| SCHEMBL9765591 | 0.79 | FFAR1 (0.54) | KDM4E | |
| SCHEMBL1299892 | 0.74 | HPGD (1.00) | HPGDPTPN1POLBMAOAMAOB | |
| SCHEMBL1299891 | 0.74 | HPGD (1.00) | HPGDPTPN1POLBMAOAMAOB | |
| SCHEMBL6865889 | 0.74 | HPGD (1.00) | HPGDPTPN1POLBMAOAMAOB | |
| SCHEMBL934310 | 0.71 | HPGD (1.00) | HPGDPTPN1POLBMAOAMAOB | |
| SCHEMBL15421510 | 0.71 | HPGD (1.00) | HPGDPTPN1POLBMAOAMAOB | |
| SCHEMBL934311 | 0.71 | HPGD (1.00) | HPGDPTPN1POLBMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991019704-A2 | OXA- AND THIAZOLIDINEDIONE HYPOGLYCEMIC AND HYPOCHOLESTEROLEMIC AGENTS | PFIZER INC. (US) | 1991-12-26 | — | — | WO | disclosed |
| US-5037842-A | Oxa- and thiazolidinedione hypoglycemic and hypocholesterolemic agents | PFIZER INC. (US) | 1991-08-06 | — | — | US | disclosed |