Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | PPARA | Q07869 | 2/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9765576 | 0.84 | HPGD (0.57) | KDM4EHPGDPOLB | |
| SCHEMBL9537152 | 0.81 | MAPT (0.42) | KDM4EMAPTRAB9AHSD17B10NPC1 | |
| SCHEMBL9765591 | 0.78 | FFAR1 (0.54) | KDM4EMAPTRAB9AHSD17B10NPC1 | |
| SCHEMBL5760866 | 0.78 | TLR9 (0.47) | KDM4EMAPTRAB9AHSD17B10NPC1 | |
| SCHEMBL5763009 | 0.77 | TLR9 (0.47) | KDM4EMAPTRAB9AHSD17B10NPC1 | |
| SCHEMBL9223750 | 0.75 | RAB9A (0.54) | KDM4EMAPTRAB9ANPC1TP53 | |
| SCHEMBL5760346 | 0.75 | KDM4E (0.64) | KDM4EMAPTRAB9AHSD17B10NPC1 | |
| SCHEMBL28823008 | 0.75 | MAPT (0.64) | KDM4EMAPTRAB9AHSD17B10NPC1 | |
| SCHEMBL5760665 | 0.75 | KDM4E (0.64) | KDM4EMAPTRAB9AHSD17B10NPC1 | |
| SCHEMBL2586944 | 0.75 | GPR119 (0.54) | KDM4EMAPTRAB9AHSD17B10NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0537300-B1 | Oxazolidinedione hypoglycemic and hypocholesterolemic agents | PFIZER (US) | 1995-04-26 | — | — | EP | disclosed |
| EP-0537300-A1 | OXA- AND THIAZOLIDINEDIONE HYPOGLYCEMIC AND HYPOCHOLESTEROLEMIC AGENTS. | PFIZER (US) | 1993-04-21 | — | — | EP | disclosed |
| WO-1991019704-A2 | OXA- AND THIAZOLIDINEDIONE HYPOGLYCEMIC AND HYPOCHOLESTEROLEMIC AGENTS | PFIZER INC. (US) | 1991-12-26 | — | — | WO | disclosed |
| US-5037842-A | Oxa- and thiazolidinedione hypoglycemic and hypocholesterolemic agents | PFIZER INC. (US) | 1991-08-06 | — | — | US | disclosed |