Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1C | Q13936 | 2/20 | 0.69 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.69 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.69 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11690305 | 0.94 | CACNA1C (0.61) | CACNA1CCACNA1FCACNA1DCACNA1S | |
| SCHEMBL7431826 | 0.92 | CACNA1C (0.71) | CACNA1CCACNA1FCACNA1DCACNA1S | |
| SCHEMBL11012182 | 0.90 | CACNA1C (0.65) | CACNA1CCACNA1FCACNA1DCACNA1S | |
| SCHEMBL10824016 | 0.89 | CACNA1C (0.64) | CACNA1CCACNA1FCACNA1DCACNA1S | |
| SCHEMBL9765688 | 0.89 | CACNA1C (0.74) | CACNA1CCACNA1FCACNA1DCACNA1S | |
| SCHEMBL11111510 | 0.89 | CACNA1F (0.63) | CACNA1CCACNA1FCACNA1DCACNA1S | |
| SCHEMBL9765702 | 0.87 | CACNA1C (0.66) | CACNA1CCACNA1FCACNA1DCACNA1S | |
| SCHEMBL11869125 | 0.87 | CACNA1C (0.66) | CACNA1CCACNA1FCACNA1DCACNA1S | |
| SCHEMBL10988598 | 0.87 | CACNA1F (0.61) | CACNA1CCACNA1FCACNA1DCACNA1S | |
| SCHEMBL11522396 | 0.86 | CACNA1C (0.59) | CACNA1CCACNA1FCACNA1DCACNA1S |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4988717-A | Optically active 1,4-dihydropyridine esters useful for treating circulatory illnesses | BAYER AKTIENGESELLSCHAFT (DE) | 1991-01-29 | — | — | US | disclosed |
| US-4849433-A | The compound, (⃡)1,4-dihydro-2,6-dimethyl-4-(2'-nitrophenyl)-pyridine-3,5-dicarboxylic acid, methyl isobutyl ester, compositions containing same and a method for effecting coronary dilation | BAYER AKTIENGESELLSCHAFT (DE) | 1989-07-18 | — | — | US | disclosed |
| US-4510310-A | 1,4-Dihydro-2,6-dimethyl-4-(2'-chlorophenyl)-3,5-dicarboxylic acid,methyl or ethyl,trifluoroethyl ester | BAYER AKTIENGESELLSCHAFT (DE) | 1985-04-09 | — | — | US | disclosed |