Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 6/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13744640 | 0.93 | ALDH1A1 (0.41) | KDM4EMAPK1HIF1AMTNR1AMTNR1B | |
| SCHEMBL13135507 | 0.92 | ACHE (0.39) | KDM4EMAPK1HIF1AMTNR1AMTNR1B | |
| SCHEMBL13135925 | 0.91 | ACHE (0.41) | KDM4EMAPK1HIF1AMTNR1AMTNR1B | |
| SCHEMBL13135926 | 0.91 | ACHE (0.41) | KDM4EMAPK1HIF1AMTNR1AMTNR1B | |
| SCHEMBL13135923 | 0.91 | ACHE (0.41) | KDM4EMAPK1HIF1AMTNR1AMTNR1B | |
| SCHEMBL13136119 | 0.88 | PIK3CD (0.43) | KDM4EMAPK1HIF1AMTNR1AMTNR1B | |
| SCHEMBL21167214 | 0.86 | KDM4E (0.41) | KDM4EMTNR1AMTNR1BALDH1A1DRD3 | |
| SCHEMBL13744850 | 0.83 | KDM4E (0.42) | KDM4EMAPK1HIF1AMTNR1AMTNR1B | |
| SCHEMBL13135499 | 0.80 | KMT2A (0.44) | KDM4EMAPK1HIF1ADRD3ADRA1A | |
| SCHEMBL13136215 | 0.80 | KDM4E (0.41) | KDM4EMAPK1HIF1AMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130217680-A1 | Inhibitors of the Renal Outer Medullary Potassium Channel | MERCK SHARP & DOHME LLC | 2013-08-22 | — | — | US | disclosed |
| US-5010108-A | Treatment of gastrointestinal disorders | POLI INDUSTRIA CHIMICA S.P.A. (IT) | 1991-04-23 | — | — | US | disclosed |
| EP-0333073-A2 | N-cycloalkylaminoethylbenzamide derivatives, their synthesis and pharmaceutical preparations | POLI INDUSTRIA CHIMICA S.p.A. (IT) | 1989-09-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130217680-A1 | Inhibitors of the Renal Outer Medullary Potassium Channel | KCNJ11, KCNJ1, KCNJ2 | KDM4E 1908/4885MAPK1 211/4885HIF1A 1281/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.