Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1L1 | Q9UHC9 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.41 |
| ▸ | EBP | Q15125 | 1/20 | 0.41 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | BLM | P54132 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | MDM4 | O15151 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.40 |
| ▸ | VDR | P11473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9766722 | 0.84 | HMGCR (0.46) | NPC1L1USP2LMNATP53MEN1 | |
| SCHEMBL9766820 | 0.84 | HMGCR (0.46) | NPC1L1USP2LMNATP53MEN1 | |
| SCHEMBL9766757 | 0.81 | CDC25A (0.43) | EBP | |
| SCHEMBL9766760 | 0.81 | CDC25A (0.43) | EBP | |
| SCHEMBL9766744 | 0.81 | GPBAR1 (0.53) | USP2LMNATP53MEN1KMT2A | |
| SCHEMBL9766739 | 0.81 | GPBAR1 (0.53) | USP2LMNATP53MEN1KMT2A | |
| SCHEMBL8408232 | 0.74 | NPC1L1 (0.58) | NPC1L1USP2LMNATP53MEN1 | |
| SCHEMBL10337844 | 0.74 | NPC1L1 (0.58) | NPC1L1USP2LMNATP53MEN1 | |
| SCHEMBL12125083 | 0.74 | NPC1L1 (0.58) | NPC1L1USP2LMNATP53MEN1 | |
| SCHEMBL9912381 | 0.74 | NPC1L1 (0.58) | NPC1L1USP2LMNATP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5023250-A | Anticholesterol agents | SMITHKLINE BEECHAM CORPORATION (US) | 1991-06-11 | — | — | US | disclosed |