Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | APEX1 | P27695 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | ELANE | P08246 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 3/20 | 0.45 |
| ▸ | CA2 | P00918 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA3 | P07451 | 1/20 | 0.41 |
| ▸ | TYR | P14679 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4595754 | 0.86 | TDP1 (0.50) | POLBTDP1APEX1HTTTSHR | |
| Terephthalic Acid SCHEMBL27538094 | 0.82 | POLB (0.53) | POLBTDP1APEX1HTTTSHR | |
| Terephthalic Acid SCHEMBL21836147 | 0.82 | ALDH1A1 (0.62) | POLBTDP1APEX1HTTTSHR | |
| Phthalic Acid SCHEMBL6916601 | 0.81 | ALDH1A1 (0.52) | TDP1HTTTSHRELANECA1 | |
| SCHEMBL4198420 | 0.80 | ALDH1A1 (0.55) | TDP1TSHRELANEALDH1A1HSD17B10 | |
| SCHEMBL346685 | 0.78 | ELANE (0.72) | POLBTDP1APEX1HTTTSHR | |
| Terephthalic Acid SCHEMBL28859780 | 0.78 | TSHR (0.63) | POLBTDP1APEX1HTTTSHR | |
| Terephthalic Acid SCHEMBL10736240 | 0.78 | TSHR (0.63) | POLBTDP1APEX1HTTTSHR | |
| Benzoic Acid SCHEMBL27830619 | 0.78 | ELANE (0.49) | POLBTDP1APEX1HTTTSHR | |
| Terephthalic Acid SCHEMBL1929898 | 0.78 | TSHR (0.71) | POLBTDP1TSHRTP53CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5049631-A | Heat resistant | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1991-09-17 | — | — | US | disclosed |