Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.40 |
| ▸ | TLR3 | O15455 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | PNMT | P11086 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9767134 | 1.00 | AKR1B1 (0.40) | AKR1B1TLR3MAPTNPSR1CACNA1C | |
| SCHEMBL9767130 | 1.00 | AKR1B1 (0.40) | AKR1B1TLR3MAPTNPSR1CACNA1C | |
| SCHEMBL7961450 | 0.90 | AKR1B1 (0.40) | AKR1B1TLR3MAPTNPSR1CACNA1C | |
| SCHEMBL7965091 | 0.88 | TLR3 (0.40) | AKR1B1TLR3MAPTCACNA1CHSP90AA1 | |
| SCHEMBL9767097 | 0.87 | TLR3 (0.39) | AKR1B1TLR3MAPTNPSR1CACNA1C | |
| SCHEMBL9767103 | 0.87 | TLR3 (0.39) | AKR1B1TLR3MAPTNPSR1CACNA1C | |
| SCHEMBL9767111 | 0.87 | TLR3 (0.39) | AKR1B1TLR3MAPTNPSR1CACNA1C | |
| SCHEMBL9195025 | 0.84 | ABCC9 (0.44) | AKR1B1TLR3MAPTHSP90AA1HIF1A | |
| SCHEMBL9195034 | 0.84 | ABCC9 (0.44) | AKR1B1TLR3MAPTHSP90AA1HIF1A | |
| SCHEMBL9195046 | 0.84 | ABCC9 (0.44) | AKR1B1TLR3MAPTHSP90AA1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5072006-A | Chemical intermeidate; hypotensive agents, muscle relaxants | RECHERCHE SYNTEX FRANCE S.A. (FR) | 1991-12-10 | — | — | US | disclosed |
| US-4997846-A | Smooth muscle relaxants, hypotensives | RESEARCHE SYNTEX FRANCE, S.A. (FR) | 1991-03-05 | — | — | US | disclosed |
| EP-0377966-A2 | Novel benzopyranylpyrrolinone derivatives | RECHERCHE SYNTEX FRANCE SA (FR) | 1990-07-18 | — | — | EP | disclosed |