Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MANBA | O00462 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | PNMT | P11086 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | THPO | P40225 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9767280 | 1.00 | MANBA (0.39) | MANBAMAPTNPSR1AKR1B1CACNA1C | |
| SCHEMBL9767628 | 0.88 | MAOB (0.35) | MANBAMAPTNPSR1AKR1B1CACNA1C | |
| SCHEMBL9767624 | 0.88 | MAOB (0.35) | MANBAMAPTNPSR1AKR1B1CACNA1C | |
| SCHEMBL9767148 | 0.83 | HIF1A (0.39) | MAPTNPSR1AKR1B1ALDH1A1CYP3A4 | |
| SCHEMBL9767152 | 0.83 | HIF1A (0.39) | MAPTNPSR1AKR1B1ALDH1A1CYP3A4 | |
| SCHEMBL9767270 | 0.77 | POLB (0.39) | MAPTAKR1B1ADRA2APNMTADRA2B | |
| SCHEMBL5695096 | 0.77 | MAOB (0.38) | MANBAMAPTNPSR1AKR1B1ALDH1A1 | |
| SCHEMBL9767097 | 0.74 | TLR3 (0.39) | MAPTNPSR1AKR1B1CACNA1CALDH1A1 | |
| SCHEMBL9767103 | 0.74 | TLR3 (0.39) | MAPTNPSR1AKR1B1CACNA1CALDH1A1 | |
| SCHEMBL9767130 | 0.74 | AKR1B1 (0.40) | MAPTNPSR1AKR1B1CACNA1CADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5072006-A | Chemical intermeidate; hypotensive agents, muscle relaxants | RECHERCHE SYNTEX FRANCE S.A. (FR) | 1991-12-10 | — | — | US | disclosed |
| US-4997846-A | Smooth muscle relaxants, hypotensives | RESEARCHE SYNTEX FRANCE, S.A. (FR) | 1991-03-05 | — | — | US | disclosed |
| EP-0377966-A2 | Novel benzopyranylpyrrolinone derivatives | RECHERCHE SYNTEX FRANCE SA (FR) | 1990-07-18 | — | — | EP | disclosed |