Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | PNMT | P11086 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 6/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 6/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9767261 | 0.89 | MAOB (0.36) | POLBADRA2AAKR1B1ALDH1A1TDP1 | |
| SCHEMBL9767027 | 0.83 | TSHR (0.38) | AKR1B1TSHRLMNAALDH1A1TDP1 | |
| SCHEMBL9767280 | 0.77 | MANBA (0.39) | POLBADRA2APNMTADRA2BADRA2C | |
| SCHEMBL9767276 | 0.77 | MANBA (0.39) | POLBADRA2APNMTADRA2BADRA2C | |
| SCHEMBL6978574 | 0.74 | HSP90AA1 (0.36) | TSHRLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL9767412 | 0.73 | DRD2 (0.38) | MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL5695096 | 0.72 | MAOB (0.38) | POLBAKR1B1LMNAALDH1A1TDP1 | |
| SCHEMBL9766984 | 0.70 | LMNA (0.37) | POLBADRA2APNMTADRA2BADRA2C | |
| SCHEMBL9767087 | 0.70 | AKR1B1 (0.39) | POLBADRA2APNMTADRA2BADRA2C | |
| SCHEMBL28863681 | 0.69 | ALDH1A1 (0.41) | ADRA2APNMTADRA2BADRA2CAKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5072006-A | Chemical intermeidate; hypotensive agents, muscle relaxants | RECHERCHE SYNTEX FRANCE S.A. (FR) | 1991-12-10 | — | — | US | disclosed |
| US-4997846-A | Smooth muscle relaxants, hypotensives | RESEARCHE SYNTEX FRANCE, S.A. (FR) | 1991-03-05 | — | — | US | disclosed |
| EP-0377966-A2 | Novel benzopyranylpyrrolinone derivatives | RECHERCHE SYNTEX FRANCE SA (FR) | 1990-07-18 | — | — | EP | disclosed |