Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MANBA | O00462 | 1/20 | 0.35 |
| ▸ | ESPL1 | Q14674 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.33 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.33 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.33 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9767624 | 1.00 | MAOB (0.35) | MAOBMAPTNPSR1MANBAESPL1 | |
| SCHEMBL5695096 | 0.88 | MAOB (0.38) | MAOBMAPTNPSR1MANBAESPL1 | |
| SCHEMBL9767280 | 0.88 | MANBA (0.39) | MAPTNPSR1MANBAAKR1B1POLB | |
| SCHEMBL9767276 | 0.88 | MANBA (0.39) | MAPTNPSR1MANBAAKR1B1POLB | |
| SCHEMBL9767148 | 0.79 | HIF1A (0.39) | MAPTNPSR1AKR1B1ALDH1A1TDP1 | |
| SCHEMBL9767152 | 0.79 | HIF1A (0.39) | MAPTNPSR1AKR1B1ALDH1A1TDP1 | |
| SCHEMBL9767261 | 0.79 | MAOB (0.36) | MAOBMAPTESPL1AKR1B1POLB | |
| SCHEMBL9766987 | 0.76 | KCNE1 (0.41) | MEN1KMT2A | |
| SCHEMBL9767527 | 0.74 | ESPL1 (0.42) | MAPTNPSR1ESPL1AKR1B1POLB | |
| SCHEMBL9865865 | 0.74 | ESPL1 (0.42) | MAPTNPSR1ESPL1AKR1B1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5072006-A | Chemical intermeidate; hypotensive agents, muscle relaxants | RECHERCHE SYNTEX FRANCE S.A. (FR) | 1991-12-10 | — | — | US | disclosed |
| US-4997846-A | Smooth muscle relaxants, hypotensives | RESEARCHE SYNTEX FRANCE, S.A. (FR) | 1991-03-05 | — | — | US | disclosed |
| EP-0377966-A2 | Novel benzopyranylpyrrolinone derivatives | RECHERCHE SYNTEX FRANCE SA (FR) | 1990-07-18 | — | — | EP | disclosed |