Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 6/20 | 0.54 |
| ▸ | HPGD | P15428 | 5/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | PGR | P06401 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5992775 | 0.88 | MAPT (0.55) | MAPTMAPK1KDM4EHSD17B10ALOX15 | |
| SCHEMBL2493749 | 0.82 | ALDH1A1 (0.59) | MAPTKDM4EHSD17B10HPGDHTT | |
| SCHEMBL9319733 | 0.81 | HPGD (0.64) | MAPTMAPK1KDM4EHSD17B10ALOX15 | |
| SCHEMBL28355059 | 0.80 | BCL2 (0.58) | MAPTMAPK1KDM4EHSD17B10LMNA | |
| SCHEMBL7939201 | 0.80 | MAPT (0.64) | MAPTMAPK1KDM4EHSD17B10ALOX15 | |
| SCHEMBL257274 | 0.80 | MAPT (0.62) | MAPTMAPK1KDM4EHSD17B10ALOX15 | |
| SCHEMBL3224251 | 0.80 | NPC1 (0.81) | MAPTMAPK1KDM4EHSD17B10ALOX15 | |
| SCHEMBL30205105 | 0.80 | NPC1 (0.81) | MAPTMAPK1KDM4EHSD17B10ALOX15 | |
| SCHEMBL1259349 | 0.79 | ALDH1A1 (0.46) | MAPK1KDM4EHSD17B10LMNAHPGD | |
| SCHEMBL3148110 | 0.79 | MAPT (0.65) | MAPTMAPK1KDM4EHSD17B10ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449465-B2 | Triazolopyrimidine derivatives as glycogen synthase kinase 3 inhibitors | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-11-11 | — | — | US | disclosed |
| US-7449465-B2 | Triazolopyrimidine derivatives as glycogen synthase kinase 3 inhibitors | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-11-11 | — | — | US | disclosed |
| US-5073611-A | Containing photoreactive compound capable of abstracting hydrogen; coatings, hot melt adhesives | BASF AKTIENGESELLSCHAFT (DE) | 1991-12-17 | — | — | US | disclosed |