Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | TRPM2 | O94759 | 2/20 | 0.43 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 6/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | UBE2I | P63279 | 1/20 | 0.42 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL9767853 | 0.86 | SMN1; SMN2 (0.46) | RAB9ASMN1; SMN2NPC1KMT2AMEN1 | |
| SCHEMBL13854028 | 0.83 | RAB9A (0.69) | RAB9ASMN1; SMN2NPC1KMT2AMEN1 | |
| SCHEMBL9767854 | 0.83 | RAB9A (0.69) | RAB9ASMN1; SMN2NPC1KMT2AMEN1 | |
| SCHEMBL9768217 | 0.82 | RAB9A (0.67) | RAB9ASMN1; SMN2NPC1KMT2AMEN1 | |
| Tranilast SCHEMBL21722775 | 0.77 | MEN1 (0.72) | RAB9ASMN1; SMN2NPC1KMT2AMEN1 | |
| Phthalic Acid SCHEMBL19210211 | 0.73 | GSR (0.67) | KMT2AALDH1A1POLBTDP1PKM | |
| Phthalic Acid SCHEMBL19210210 | 0.73 | GSR (0.67) | KMT2AALDH1A1POLBTDP1PKM | |
| SCHEMBL9767835 | 0.72 | RAB9A (0.66) | RAB9ASMN1; SMN2NPC1KMT2AMEN1 | |
| Potassium Ion SCHEMBL9767821 | 0.72 | RAB9A (0.66) | RAB9ASMN1; SMN2NPC1KMT2AMEN1 | |
| SCHEMBL9768214 | 0.72 | RAB9A (0.66) | RAB9ASMN1; SMN2NPC1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006548-A | Hyaluronidase inhibitors, antiallergens, immunomodulators | SAWAI PHARMACEUTICAL CO., LTD. (JP) | 1991-04-09 | — | — | US | disclosed |
| EP-0153850-B1 | ACRYLAMIDOBENZOIC ACID DERIVATIVES AND THEIR USE | SAWAI PHARMACEUTICAL CO., LTD. (JP) | 1989-09-13 | — | — | EP | disclosed |
| EP-0153850-A1 | Acrylamidobenzoic acid derivatives and their use | SAWAI PHARMACEUTICAL CO., LTD. (JP) | 1985-09-04 | — | — | EP | disclosed |