Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 2/20 | 0.41 |
| ▸ | DPP4 | P27487 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7313734 | 1.00 | KMT2A (0.49) | KMT2AKDM4ECYP2D6HTTTDP1 | |
| SCHEMBL7959886 | 0.88 | KDM4E (0.47) | KMT2AKDM4ECYP2D6HTTPOLB | |
| SCHEMBL7973302 | 0.88 | KDM4E (0.47) | KMT2AKDM4ECYP2D6HTTPOLB | |
| SCHEMBL7973454 | 0.88 | KDM4E (0.47) | KMT2AKDM4ECYP2D6HTTPOLB | |
| SCHEMBL7973306 | 0.88 | KDM4E (0.47) | KMT2AKDM4ECYP2D6HTTPOLB | |
| SCHEMBL28860925 | 0.88 | KDM4E (0.47) | KMT2AKDM4ECYP2D6HTTPOLB | |
| SCHEMBL7976128 | 0.88 | KDM4E (0.47) | KMT2AKDM4ECYP2D6HTTPOLB | |
| SCHEMBL7959881 | 0.88 | KDM4E (0.47) | KMT2AKDM4ECYP2D6HTTPOLB | |
| SCHEMBL24359262 | 0.85 | KMT2A (0.45) | KMT2AKDM4ECYP2D6HTTTDP1 | |
| SCHEMBL7305362 | 0.85 | KMT2A (0.45) | KMT2AKDM4ECYP2D6HTTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2448935-A1 | SUBSTITUTED 2-CARBOXAMIDE CYCLOAMINO UREAS | Novartis AG (CH) | 2012-05-09 | — | — | EP | disclosed |
| WO-2011000905-A1 | SUBSTITUTED 2-CARBOXAMIDE CYCLOAMINO UREAS | NOVARTIS AG (CH) | 2011-01-06 | — | — | WO | disclosed |