Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.82 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.82 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.82 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.82 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.57 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.56 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | KDM5C | P41229 | 3/20 | 0.50 |
| ▸ | PHF8 | Q9UPP1 | 3/20 | 0.50 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.50 |
| ▸ | KDM6B | O15054 | 2/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL29420129 | 0.95 | LMNA (0.90) | LMNAEGLN1ALKBH5SUCNR1SLC22A6 | |
| Succinic Acid SCHEMBL9420932 | 0.91 | LMNA (0.82) | LMNAEGLN1ALKBH5SUCNR1SLC22A6 | |
| Succinic Acid SCHEMBL28297794 | 0.91 | LMNA (0.82) | LMNAEGLN1ALKBH5SUCNR1SLC22A6 | |
| Succinic Acid SCHEMBL28493423 | 0.91 | LMNA (0.82) | LMNAEGLN1ALKBH5SUCNR1SLC22A6 | |
| Succinic Acid SCHEMBL28247570 | 0.91 | LMNA (0.82) | LMNAEGLN1ALKBH5SUCNR1SLC22A6 | |
| Succinic Acid SCHEMBL3759132 | 0.91 | LMNA (0.82) | LMNAEGLN1ALKBH5SUCNR1SLC22A6 | |
| Succinic Acid SCHEMBL28082369 | 0.91 | LMNA (0.82) | LMNAEGLN1ALKBH5SUCNR1SLC22A6 | |
| Succinic Acid SCHEMBL27885647 | 0.91 | LMNA (0.82) | LMNAEGLN1ALKBH5SUCNR1SLC22A6 | |
| Succinic Acid SCHEMBL29905033 | 0.91 | LMNA (0.82) | LMNAEGLN1ALKBH5SUCNR1SLC22A6 | |
| Succinic Acid SCHEMBL57199 | 0.91 | LMNA (0.82) | LMNAEGLN1ALKBH5SUCNR1SLC22A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4353248-A1 | CALCIUM-SENSING RECEPTOR AGONIST COMPOSITION AND APPLICATION THEREOF | Beijing Tuo Jie Biopharmaceutical Co. Ltd. (CN) | 2024-04-17 | — | — | EP | disclosed |
| EP-3143047-B1 | BELIMUMAB FORMULATION | GLAXOSMITHKLINE INTELLECTUAL PROPERTY MAN LIMITED (GB) | 2022-07-20 | — | — | EP | disclosed |
| EP-3719038-A1 | BELIMUMAB FORMULATION | GlaxoSmithKline Intellectual Property Management Limited (GB) | 2020-10-07 | — | — | EP | disclosed |
| EP-3715371-A1 | BELIMUMAB FORMULATION | GlaxoSmithKline Intellectual Property Management Limited (GB) | 2020-09-30 | — | — | EP | disclosed |
| CN-109203748-A | Ink jet recording method and ink-jet recording apparatus | 佳能株式会社 | 2019-01-15 | — | — | CN | disclosed |
| CN-106916488-A | Ink, print cartridge and ink jet recording method | 佳能株式会社 | 2017-07-04 | — | — | CN | disclosed |
| EP-3143047-A1 | ANTIBODY FORMULATION | GlaxoSmithKline Intellectual Property Management Limited (GB) | 2017-03-22 | — | — | EP | disclosed |
| WO-2015173782-A1 | ANTIBODY FORMULATION | GLAXOSMITHKLINE INTELLECTUAL PROPERTY MANAGEMENT LIMITED (GB) | 2015-11-19 | — | — | WO | disclosed |
| CN-103755670-B | A kind of Andrographolide compound and pharmaceutical composition thereof | HUBEI MERRYCLIN PHARMACEUTICAL CO., LTD. (CN) | 2015-08-12 | — | — | CN | disclosed |
| CN-103755670-A | Potassium sodium dehydroandroan drographolide succinate compound and pharmaceutical composition thereof | HUBEI MERRYCLIN PHARMACEUTICAL CO LTD | 2014-04-30 | — | — | CN | disclosed |
| CN-102382082-A | Novel potassium sodium dehydroandroan drographolide succinate compound and drug combination thereof | XIAODONG ZHOU | 2012-03-21 | — | — | CN | disclosed |
| US-4999207-A | Improving Bitter Aftertaste of Foods Sweetened with Aspartame | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1991-03-12 | — | — | US | disclosed |
| US-4988532-A | IMPROVING TASTE OF COFFEE WITH SCLAEROLIDE | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1991-01-29 | — | — | US | disclosed |
| US-4988527-A | ENHANCING SALT TASTE OF FOODS, SUBSTITUTE FOR SODIUM CHLORIDE | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1991-01-29 | — | — | US | disclosed |
| US-4966783-A | Flavoring icecream or other dairy products | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1990-10-30 | — | — | US | disclosed |
| US-4960603-A | Flavors for seafood | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1990-10-02 | — | — | US | disclosed |
| US-4917913-A | Use of sclareolide in augmenting or enhancing the organoleptic properties of foodstuffs | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1990-04-17 | — | — | US | disclosed |
| US-4514094-A | APPARATUS USING ELECTRONIC PROGRAM CONTROL | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1985-04-30 | — | — | US | disclosed |
| US-4514431-A | LACTIC ACID AND/OR THE POTASSIUM SALT, A POTASSIUM COMPOUND AND A POTASSIUM HALIDE | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1985-04-30 | — | — | US | disclosed |
| US-4471002-A | PHOSPHATES, POTASSIUM AND SODIUM COMPOUNDS, LACTIC ACID | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1984-09-11 | — | — | US | disclosed |