Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.82 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.82 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.82 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.82 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.57 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.56 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | KDM5C | P41229 | 3/20 | 0.50 |
| ▸ | PHF8 | Q9UPP1 | 3/20 | 0.50 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.50 |
| ▸ | KDM6B | O15054 | 2/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL29420129 | 0.95 | LMNA (0.90) | LMNAEGLN1ALKBH5SUCNR1SLC22A6 | |
| Succinic Acid SCHEMBL27549020 | 0.91 | LMNA (0.82) | LMNAEGLN1ALKBH5SUCNR1SLC22A6 | |
| Succinic Acid SCHEMBL19463716 | 0.91 | LMNA (0.82) | LMNAEGLN1ALKBH5SUCNR1SLC22A6 | |
| Succinic Acid SCHEMBL28082369 | 0.91 | LMNA (0.82) | LMNAEGLN1ALKBH5SUCNR1SLC22A6 | |
| Succinic Acid SCHEMBL3759132 | 0.91 | LMNA (0.82) | LMNAEGLN1ALKBH5SUCNR1SLC22A6 | |
| Succinic Acid SCHEMBL28247570 | 0.91 | LMNA (0.82) | LMNAEGLN1ALKBH5SUCNR1SLC22A6 | |
| Succinic Acid SCHEMBL9768437 | 0.91 | LMNA (0.82) | LMNAEGLN1ALKBH5SUCNR1SLC22A6 | |
| Succinic Acid SCHEMBL27885647 | 0.91 | LMNA (0.82) | LMNAEGLN1ALKBH5SUCNR1SLC22A6 | |
| Succinic Acid SCHEMBL29905033 | 0.91 | LMNA (0.82) | LMNAEGLN1ALKBH5SUCNR1SLC22A6 | |
| Succinic Acid SCHEMBL4269130 | 0.91 | LMNA (1.00) | LMNAEGLN1ALKBH5SUCNR1SLC22A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1556 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114246953-B | Anti-cMet antibody drug conjugates and methods of use thereof | 艾伯维生物制药股份有限公司 | 2024-07-09 | — | — | CN | claimed |
| CN-116763917-A | Stable anti-human IL15/PD-L1 bifunctional fusion protein preparation | 上海齐鲁制药研究中心有限公司 | 2023-09-19 | — | — | CN | claimed |
| EP-3837273-A1 | IMPROVED PROTEIN RECOVERY | Bristol-Myers Squibb Company (US) | 2021-06-23 | — | — | EP | claimed |
| US-20210171573-A1 | IMPROVED PROTEIN RECOVERY | BRISTOL-MYERS SQUIBB COMPANY | 2021-06-10 | — | — | US | claimed |
| CN-112881709-A | Protein solubility screening formula kit and application thereof | 普罗稳定股份有限公司 | 2021-06-01 | — | — | CN | claimed |
| CN-112566920-A | Improved protein recovery | 百时美施贵宝公司 | 2021-03-26 | — | — | CN | claimed |
| WO-2020036903-A1 | IMPROVED PROTEIN RECOVERY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-02-20 | — | — | WO | claimed |
| CN-1747722-A | Sugar-free oral transmucosal solid dosage forms and uses thereof | CEPHALON INC (US) | 2006-03-15 | — | — | CN | claimed |
| US-20040253307-A1 | Sugar-free oral transmucosal solid dosage forms and uses thereof | CEPHALON, INC. | 2004-12-16 | — | — | US | claimed |
| US-6165954-A | Enzyme compositions and methods for contact lens cleaning | ALLERGAN, INC. (US) | 2000-12-26 | — | — | US | claimed |
| US-5746838-A | TIME-RELEASE ENZYME DEACTIVATION | ALLERGAN (US) | 1998-05-05 | — | — | US | claimed |
| EP-0387784-B1 | Quantitative determination of bilirubin and a reagent therefor | UNITIKA LTD (JP) | 1997-09-10 | — | — | EP | claimed |
| US-5654156-A | PREPARING REAGENT COMPRISING LIPOSOMES CONTAINING ANTIGEN OR ANTIBODY WHICH BINDS ANALYTE TO BE MEASURED, ENCAPSULATING MARKER THEREIN, ACIDIFYING SAMPLE, CONTACTING SAMPLE WITH REAGENT, MEASURING AMOUNT OF DETECTABLE MARKER RELEASED | WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) | 1997-08-05 | — | — | US | claimed |
| US-5104794-A | Deconjugation of conjugated bilirubins to be measured using high performance liquid chromatography | UNITIKA LTD. (JP) | 1992-04-14 | — | — | US | claimed |
| EP-0387784-A2 | Quantitative determination of bilirubin and a reagent therefor | UNITIKA LTD. (JP) | 1990-09-19 | — | — | EP | claimed |
| WO-2024206126-A1 | CD16-BINDING ANTIBODIES AND USES THEREOF | MODERNATX, INC. (US) | 2024-10-03 | — | — | WO | disclosed |
| WO-2024206209-A1 | ANTI-CD38, ANTI-BCMA, ANTI-GPRC5D, AND ANTI-FCRH5 ANTIBODIES AND USES TO TREAT VARIOUS DISEASES SUCH AS CANCER | MODERNATX, INC. (US) | 2024-10-03 | — | — | WO | disclosed |
| US-4605556-A | APPLYING INTERFERON, POLYHYDRIC SUGAR ALCOHOL, AND ORGANIC ACID BUFFER | SUN STAR KABUSHIKI KAISHA (JP) | 1986-08-12 | — | — | US | disclosed |
| US-4605555-A | INTERFERON, POLYHYDRIC SUGAR ALCOHOL, ORGANIC ACID BUFFER | SUN STAR KABUSHIKI KAISHA (JP) | 1986-08-12 | — | — | US | disclosed |
| EP-0080879-A2 | Pharmaceutical composition containing interferon in stable state | SUNSTAR KABUSHIKI KAISHA (JP) | 1983-06-08 | — | — | EP | disclosed |