Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 3/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.59 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.59 |
| ▸ | CA4 | P22748 | 3/20 | 0.53 |
| ▸ | CA1 | P00915 | 4/20 | 0.53 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL3012461 | 0.96 | HDAC3 (0.62) | HDAC3HDAC1HDAC2HDAC8FFAR3 | |
| Succinic Acid SCHEMBL24440 | 0.96 | HDAC3 (0.62) | HDAC3HDAC1HDAC2HDAC8FFAR3 | |
| Succinic Acid SCHEMBL63118 | 0.92 | HDAC3 (0.59) | HDAC3HDAC1HDAC2HDAC8FFAR3 | |
| Succinic Acid SCHEMBL7569477 | 0.92 | HDAC3 (0.59) | HDAC3HDAC1HDAC2HDAC8FFAR3 | |
| Succinic Acid SCHEMBL17311430 | 0.92 | HDAC3 (0.59) | HDAC3HDAC1HDAC2HDAC8FFAR3 | |
| Succinic Acid SCHEMBL351829 | 0.92 | HDAC3 (0.59) | HDAC3HDAC1HDAC2HDAC8FFAR3 | |
| Succinic Acid SCHEMBL11211761 | 0.92 | HDAC3 (0.59) | HDAC3HDAC1HDAC2HDAC8FFAR3 | |
| Succinic Acid SCHEMBL2923816 | 0.92 | FFAR3 (0.59) | HDAC3HDAC1HDAC2HDAC8FFAR3 | |
| Succinic Acid SCHEMBL8441137 | 0.92 | HDAC3 (0.59) | HDAC3HDAC1HDAC2HDAC8FFAR3 | |
| Succinic Acid SCHEMBL7759484 | 0.92 | HDAC3 (0.59) | HDAC3HDAC1HDAC2HDAC8FFAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4999207-A | Improving Bitter Aftertaste of Foods Sweetened with Aspartame | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1991-03-12 | — | — | US | disclosed |
| US-4988532-A | IMPROVING TASTE OF COFFEE WITH SCLAEROLIDE | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1991-01-29 | — | — | US | disclosed |
| US-4988527-A | ENHANCING SALT TASTE OF FOODS, SUBSTITUTE FOR SODIUM CHLORIDE | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1991-01-29 | — | — | US | disclosed |
| US-4966783-A | Flavoring icecream or other dairy products | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1990-10-30 | — | — | US | disclosed |
| US-4960603-A | Flavors for seafood | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1990-10-02 | — | — | US | disclosed |
| US-4917913-A | Use of sclareolide in augmenting or enhancing the organoleptic properties of foodstuffs | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1990-04-17 | — | — | US | disclosed |
| US-4514094-A | APPARATUS USING ELECTRONIC PROGRAM CONTROL | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1985-04-30 | — | — | US | disclosed |
| US-4514431-A | LACTIC ACID AND/OR THE POTASSIUM SALT, A POTASSIUM COMPOUND AND A POTASSIUM HALIDE | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1985-04-30 | — | — | US | disclosed |
| US-4471002-A | PHOSPHATES, POTASSIUM AND SODIUM COMPOUNDS, LACTIC ACID | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1984-09-11 | — | — | US | disclosed |