Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | GSK3B | P49841 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 5/20 | 0.42 |
| ▸ | CES2 | O00748 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10566591 | 0.90 | PTPN1 (0.47) | GSK3BALDH1A1HIF1AL3MBTL1LMNA | |
| SCHEMBL10658190 | 0.84 | MAPK1 (0.48) | MAPK1GSK3BALDH1A1TRPA1HIF1A | |
| SCHEMBL9064567 | 0.83 | GSK3B (0.47) | MAPK1GSK3BALDH1A1L3MBTL1CES1 | |
| SCHEMBL5214256 | 0.82 | GSK3B (0.47) | MAPK1GSK3BALDH1A1TRPA1HIF1A | |
| SCHEMBL9211326 | 0.81 | PTPN1 (0.44) | GSK3BALDH1A1MDM2CES1CES2 | |
| SCHEMBL10575099 | 0.81 | GSK3B (0.44) | GSK3BALDH1A1TDP1L3MBTL1CES1 | |
| SCHEMBL4935875 | 0.81 | SLC6A2 (0.53) | MAPK1GSK3BMDM2TDP1L3MBTL1 | |
| SCHEMBL2823791 | 0.81 | SLC6A2 (0.53) | MAPK1GSK3BMDM2TDP1L3MBTL1 | |
| SCHEMBL13159776 | 0.80 | ALDH1A1 (0.47) | ALDH1A1HIF1ATDP1LMNAMAPT | |
| SCHEMBL9449271 | 0.79 | NPC1 (0.49) | MAPK1GSK3BALDH1A1MDM2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5059601-A | IMIDAZOLONE DERIVATIVES WITH ACTIVITY ON CENTRAL NERVOUS SYSTEM AND ANTIHYPERTENSIVE ACTIVITY, PREPARATION METHODS THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ISTITUTO LUSOFARMACO D'ITALIA S.P.A. (IT) | 1991-10-22 | — | — | US | disclosed |
| EP-0122693-B1 | ANTIFUNGAL DI(AZOLYL)PROPANOL DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1987-07-08 | — | — | EP | disclosed |
| US-4625036-A | Antifungal azole compounds | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1986-11-25 | — | — | US | disclosed |
| EP-0122693-A1 | Antifungal di(azolyl)propanol derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1984-10-24 | — | — | EP | disclosed |
| US-4061637-A | CNS, CARDIOVASCULAR, ANTIINFLAMMATORY, ADRENOLYTIC, ANTIULCER | ISTITUTO LUSO FARMACO D'ITALIA S.R.L. (IT) | 1977-12-06 | — | — | US | disclosed |