Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23782492 | 0.86 | PARP10 (0.46) | NPC1RAB9AMAPK1SMN1; SMN2POLB | |
| SCHEMBL4935875 | 0.83 | SLC6A2 (0.53) | NPC1RAB9AMAPTATMMAPK1 | |
| SCHEMBL7599592 | 0.83 | PGR (0.49) | NPC1RAB9AMAPTATMMAPK1 | |
| SCHEMBL2823791 | 0.83 | SLC6A2 (0.53) | NPC1RAB9AMAPTATMMAPK1 | |
| SCHEMBL5214256 | 0.81 | GSK3B (0.47) | NPC1RAB9AMAPTATMMAPK1 | |
| SCHEMBL648332 | 0.80 | CES2 (0.47) | NPC1RAB9AMAPTATMMAPK1 | |
| SCHEMBL9768627 | 0.79 | MAPK1 (0.45) | NPC1RAB9AMAPTATMMAPK1 | |
| SCHEMBL5711629 | 0.79 | NPC1 (0.50) | NPC1RAB9AMAPTATMMAPK1 | |
| SCHEMBL1248513 | 0.79 | LCK (0.55) | NPC1RAB9AMAPTATMMAPK1 | |
| SCHEMBL10793235 | 0.79 | HPGD (0.44) | NPC1RAB9AMAPTATMMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5250546-A | Administering as therapy for spastic paralysis; glutamic acid blocking agent; agricultural chemicals | NIPPON CHEMIPHAR CO., LTD. (JP) | 1993-10-05 | — | — | US | disclosed |
| EP-0177245-B1 | AMINO-ALCOHOL DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | NIPPON CHEMIPHAR CO., LTD. (JP) | 1991-04-10 | — | — | EP | disclosed |
| EP-0177245-A2 | Amino-alcohol derivatives and processes for their preparation | NIPPON CHEMIPHAR CO., LTD. (JP) | 1986-04-09 | — | — | EP | disclosed |