Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9768711 | 0.91 | NPC1 (0.45) | NPC1MITFRAB9AMAPTALDH1A1 | |
| SCHEMBL9768779 | 0.91 | NPC1 (0.45) | NPC1MITFRAB9AMAPTALDH1A1 | |
| SCHEMBL9768718 | 0.90 | NR1I2 (0.46) | NPC1MITFRAB9AMAPTALDH1A1 | |
| SCHEMBL9768732 | 0.87 | ALDH1A1 (0.44) | MAPTALDH1A1MEN1LMNAKMT2A | |
| SCHEMBL9768785 | 0.87 | NPC1 (0.53) | NPC1MITFRAB9AALDH1A1NR1I2 | |
| SCHEMBL9768904 | 0.84 | CYP1A2 (0.48) | NPC1MITFRAB9AMAPTALDH1A1 | |
| SCHEMBL9768770 | 0.83 | NPC1 (0.45) | NPC1MITFRAB9AMAPTMEN1 | |
| SCHEMBL9768722 | 0.83 | NPC1 (0.44) | NPC1MITFRAB9AMAPTALDH1A1 | |
| SCHEMBL9768766 | 0.79 | NPC1 (0.45) | NPC1MITFRAB9AMAPTALDH1A1 | |
| SCHEMBL9768774 | 0.79 | ALDH1A1 (0.43) | MAPTALDH1A1MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5011833-A | Antidepressant | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE (IT) | 1991-04-30 | — | — | US | disclosed |
| EP-0354885-A1 | Novel derivatives of 6,11-dihydro-dibenzo[c,f][1,2,5]-thiadiazepine 5,5-dioxide, salts thereof and appropriate processes for the preparation thereof | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) | 1990-02-14 | — | — | EP | disclosed |