SCHEMBL9768970

SCHEMBL9768970

CCCC(=NN=O)c1ccncc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.40
NPSR1 Q6W5P4 1/20 0.40
HDAC3 O15379 1/20 0.38
HDAC1 Q13547 1/20 0.38
HDAC2 Q92769 1/20 0.38
NAAA Q02083 1/20 0.38
LMNA P02545 4/20 0.38
CYP1A2 P05177 4/20 0.38
CYP2C19 P33261 4/20 0.38
GAA P10253 3/20 0.38
CYP3A4 P08684 3/20 0.38
CYP2D6 P10635 3/20 0.38
CYP2C9 P11712 3/20 0.38
NPC1 O15118 2/20 0.38
SMN1; SMN2 Q16637 4/20 0.37
NFKB1 P19838 1/20 0.37
NFKB2 Q00653 1/20 0.37
RELA Q04206 1/20 0.37
NAPRT Q6XQN6 1/20 0.36
GLA P06280 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11072536 0.79 GPBAR1 (0.43) KMT2ANPSR1HDAC3HDAC1HDAC2
SCHEMBL9768797 0.78 KDM4E (0.38) KMT2ANPSR1HDAC3HDAC1HDAC2
SCHEMBL9795943 0.73 SMN1; SMN2 (0.57) KMT2ACYP1A2CYP2C19GAACYP3A4
SCHEMBL9795947 0.73 SMN1; SMN2 (0.57) KMT2ACYP1A2CYP2C19GAACYP3A4
Hydrochloric Acid SCHEMBL9795925 0.72 SMN1; SMN2 (0.56) KMT2ACYP1A2CYP2C19GAACYP3A4
Hydrochloric Acid SCHEMBL9795915 0.72 SMN1; SMN2 (0.56) KMT2ACYP1A2CYP2C19GAACYP3A4
SCHEMBL9768920 0.71 L3MBTL1 (0.52) KMT2AGAANPC1NAPRTKDM4E
Propyl 4-Pyridyl Ketone SCHEMBL4952700 0.71 HSD17B3 (0.61) KMT2ANPSR1HDAC3HDAC1HDAC2
Water SCHEMBL9768840 0.69 L3MBTL1 (0.50) KMT2AGAANPC1NAPRTKDM4E
SCHEMBL9795909 0.69 KMT2A (0.37) KMT2ANPSR1HDAC3HDAC1HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5011932-A Anthelmintic pyridinyl acylhydrazones derivatives UPJOHN COMPANY (US) 1991-04-30 US claimed
EP-0214158-A1 ANTHELMINTIC PYRIDINYL ACYLHYDRAZONES, METHOD OF USE AND COMPOSITIONS THE UPJOHN COMPANY (US) 1987-03-18 EP claimed
WO-1986004582-A1 ANTHELMINTIC PYRIDINYL ACYLHYDRAZONES, METHOD OF USE AND COMPOSITIONS THE UPJOHN COMPANY (US) 1986-08-14 WO claimed