Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.33 |
| ▸ | JAK1 | P23458 | 3/20 | 0.33 |
| ▸ | TYK2 | P29597 | 3/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | MGAM | O43451 | 2/20 | 0.31 |
| ▸ | SI | P14410 | 2/20 | 0.31 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9769377 | 1.00 | JAK2 (0.33) | JAK2JAK1TYK2JAK3ADRB2 | |
| SCHEMBL9769296 | 0.87 | ADRB2 (0.44) | JAK2JAK1TYK2JAK3ADRB2 | |
| SCHEMBL10584351 | 0.87 | ADRB2 (0.44) | JAK2JAK1TYK2JAK3ADRB2 | |
| SCHEMBL9769140 | 0.84 | KDM4E (0.43) | JAK2JAK1TYK2JAK3ADRB2 | |
| SCHEMBL9769104 | 0.84 | KDM4E (0.46) | JAK2JAK1TYK2JAK3ADRB2 | |
| SCHEMBL9769131 | 0.84 | KDM4E (0.43) | JAK2JAK1TYK2JAK3ADRB2 | |
| SCHEMBL9769111 | 0.84 | KDM4E (0.46) | JAK2JAK1TYK2JAK3ADRB2 | |
| SCHEMBL9769180 | 0.80 | — | — | |
| SCHEMBL9769173 | 0.80 | — | — | |
| SCHEMBL9769092 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5019578-A | β-adrenergic agonists | MERCK & CO., INC. (US) | 1991-05-28 | — | — | US | disclosed |