Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MGAM | O43451 | 1/20 | 0.32 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SI | P14410 | 1/20 | 0.32 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9769894 | 0.81 | ALDH1A1 (0.43) | HMGCRALDH1A1HPGDHSD17B10HSD11B1 | |
| SCHEMBL9769874 | 0.75 | HMGCR (0.54) | HMGCRALDH1A1HPGDUSP2HSD17B10 | |
| SCHEMBL9769861 | 0.73 | HMGCR (0.45) | HMGCRALDH1A1HPGDUSP2HSD17B10 | |
| SCHEMBL4681439 | 0.73 | TYMP (0.42) | HMGCRALDH1A1HPGDUSP2HSD17B10 | |
| SCHEMBL9769863 | 0.71 | HMGCR (0.56) | HMGCRALDH1A1HPGDUSP2HSD17B10 | |
| SCHEMBL10548599 | 0.71 | HMGCR (0.56) | HMGCRALDH1A1HPGDUSP2HSD17B10 | |
| SCHEMBL9769845 | 0.70 | HMGCR (0.43) | HMGCRALDH1A1USP2LMNATDP1 | |
| SCHEMBL9726535 | 0.68 | HMGCR (0.46) | HMGCRALDH1A1USP2HSD17B10SMN1; SMN2 | |
| SCHEMBL9726531 | 0.66 | POLB (0.36) | HMGCRALDH1A1HPGDUSP2HSD17B10 | |
| SCHEMBL9726584 | 0.66 | HMGCR (0.38) | HMGCRUSP2HSD17B10TDP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5070206-A | INHIBITORS OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE; ANTICHOLESTEROL, ANTILIPEMIC | BRISTOL-MYERS COMPANY (US) | 1991-12-03 | — | — | US | disclosed |
| US-5010205-A | Antihypercholesterolemic tetrazol-1-yl intermediates | BRISTOL-MYERS COMPANY (US) | 1991-04-23 | — | — | US | disclosed |
| US-4870187-A | ANTILIPEMIC, ATHEROSCLEROSIS | BRISTOL-MYERS COMPANY (US) | 1989-09-26 | — | — | US | disclosed |