Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MGAM | O43451 | 1/20 | 0.35 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SI | P14410 | 1/20 | 0.35 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | STAT5B | P51692 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9769886 | 0.81 | HMGCR (0.45) | ALDH1A1HPGDHSD11B1PKMTSHR | |
| SCHEMBL9769831 | 0.78 | ALDH1A1 (0.42) | ALDH1A1HPGDHSD11B1HDAC6SLC6A2 | |
| SCHEMBL9769828 | 0.75 | ELANE (0.43) | ALDH1A1HPGDHSD11B1HDAC6MGLL | |
| SCHEMBL9769841 | 0.74 | HMGCR (0.41) | ALDH1A1HPGDHSD11B1HDAC6SLC6A2 | |
| SCHEMBL9769846 | 0.74 | HMGCR (0.41) | ALDH1A1HPGDHSD11B1HDAC6SLC6A2 | |
| SCHEMBL10437623 | 0.68 | MEN1 (0.46) | ALDH1A1HPGDHSD11B1POLBHTT | |
| SCHEMBL5673134 | 0.67 | MGLL (0.52) | ALDH1A1HPGDHSD11B1HDAC6POLB | |
| SCHEMBL9769845 | 0.66 | HMGCR (0.43) | ALDH1A1NPC1TSHRGAALMNA | |
| SCHEMBL10437622 | 0.66 | MGLL (0.46) | ALDH1A1HPGDHSD11B1HDAC6POLB | |
| SCHEMBL12781922 | 0.65 | MGLL (0.51) | ALDH1A1HPGDHSD11B1HDAC6POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5070206-A | INHIBITORS OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE; ANTICHOLESTEROL, ANTILIPEMIC | BRISTOL-MYERS COMPANY (US) | 1991-12-03 | — | — | US | disclosed |
| US-5010205-A | Antihypercholesterolemic tetrazol-1-yl intermediates | BRISTOL-MYERS COMPANY (US) | 1991-04-23 | — | — | US | disclosed |
| EP-0355820-A1 | Antihypercholesterolemic tetrazol-1-yl compounds | Bristol-Myers Squibb Company (US) | 1990-02-28 | — | — | EP | disclosed |
| US-4870187-A | ANTILIPEMIC, ATHEROSCLEROSIS | BRISTOL-MYERS COMPANY (US) | 1989-09-26 | — | — | US | disclosed |