SCHEMBL976989

SCHEMBL976989

CC(C)(C)C1CCC(NC(=O)CN2CCNCC2)CC1

nearest known ligand 0.67

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 6/20 0.67
CHRM5 P08912 2/20 0.67
CHRM3 P20309 2/20 0.67
EPHX2 P34913 1/20 0.47
EPHX1 P07099 1/20 0.45
CA12 O43570 2/20 0.42
CA1 P00915 2/20 0.42
CA2 P00918 2/20 0.42
CA9 Q16790 2/20 0.42
KMT2A Q03164 2/20 0.40
DRD4 P21917 1/20 0.40
DRD3 P35462 1/20 0.40
LMNA P02545 1/20 0.39
TSHR P16473 1/20 0.39
KDM4E B2RXH2 1/20 0.39
PKM P14618 1/20 0.39
SMYD3 Q9H7B4 1/20 0.38
ALDH1A1 P00352 1/20 0.38
MAPK1 P28482 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11960582 0.89 SIGMAR1 (0.58) SIGMAR1CHRM5CHRM3EPHX2EPHX1
SCHEMBL1901358 0.88 SIGMAR1 (0.84) SIGMAR1CHRM5CHRM3EPHX1CA12
SCHEMBL11627783 0.84 SIGMAR1 (0.72) SIGMAR1CHRM5CHRM3CA12CA1
SCHEMBL981182 0.82 SIGMAR1 (0.74) SIGMAR1CHRM5CHRM3EPHX2CA12
SCHEMBL982065 0.82 SIGMAR1 (0.90) SIGMAR1CHRM5CHRM3CA12CA1
SCHEMBL976514 0.81 SIGMAR1 (0.68) SIGMAR1CHRM5CHRM3EPHX2CA12
SCHEMBL28391152 0.81 SIGMAR1 (0.72) SIGMAR1CHRM5CHRM3CA12CA1
Esaprazole SCHEMBL931007 0.80 SIGMAR1 (1.00) SIGMAR1CHRM5CHRM3EPHX1CA12
SCHEMBL14805838 0.78 SIGMAR1 (0.60) SIGMAR1CHRM5CHRM3CA12CA1
SCHEMBL13640016 0.78 SIGMAR1 (0.72) SIGMAR1CHRM5CHRM3CA12CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011000945-A9 AMINOALKAMIDES FOR USE IN THE TREATMENT OF INFLAMMATORY, DEGENERATIVE OR DEMYELINATING DISEASES OF THE CNS NENSIUS RESEARCH A/S (DK) 2011-04-07 WO claimed
WO-2011000945-A2 AMINOALKAMIDES FOR USE IN THE TREATMENT OF INFLAMMATORY, DEGENERATIVE OR DEMYELINATING DISEASES OF THE CNS NENSIUS RESEARCH A/S (DK) 2011-01-06 WO claimed
WO-2011000945-A9 AMINOALKAMIDES FOR USE IN THE TREATMENT OF INFLAMMATORY, DEGENERATIVE OR DEMYELINATING DISEASES OF THE CNS NENSIUS RESEARCH A/S (DK) 2011-04-07 WO disclosed
WO-2011000945-A2 AMINOALKAMIDES FOR USE IN THE TREATMENT OF INFLAMMATORY, DEGENERATIVE OR DEMYELINATING DISEASES OF THE CNS NENSIUS RESEARCH A/S (DK) 2011-01-06 WO disclosed