Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | FOLH1 | Q04609 | 6/20 | 0.61 |
| ▸ | TGM2 | P21980 | 1/20 | 0.57 |
| ▸ | ANPEP | P15144 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.56 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.56 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.55 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.55 |
| ▸ | MMP2 | P08253 | 1/20 | 0.55 |
| ▸ | MMP9 | P14780 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9772192 | 1.00 | HTT (0.64) | HTTFOLH1TGM2ANPEPLMNA | |
| SCHEMBL7775652 | 0.91 | HTT (0.61) | HTTFOLH1TGM2ANPEPLMNA | |
| SCHEMBL7775648 | 0.91 | HTT (0.61) | HTTFOLH1TGM2ANPEPLMNA | |
| SCHEMBL11000431 | 0.90 | HTT (0.58) | HTTFOLH1TGM2ANPEPLMNA | |
| SCHEMBL9772187 | 0.90 | HTT (0.58) | HTTFOLH1TGM2ANPEPLMNA | |
| SCHEMBL9772263 | 0.89 | TGM2 (0.57) | HTTFOLH1TGM2ANPEPLMNA | |
| SCHEMBL9772251 | 0.89 | HTT (0.56) | HTTFOLH1TGM2ANPEPLMNA | |
| SCHEMBL9772245 | 0.89 | HTT (0.56) | HTTFOLH1TGM2ANPEPLMNA | |
| SCHEMBL22171710 | 0.88 | HTT (0.62) | HTTFOLH1TGM2ANPEPLMNA | |
| SCHEMBL19019738 | 0.87 | TGM2 (0.61) | HTTFOLH1TGM2ANPEPLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4983328-A | ANTITUMOR AGENTS | BRISTOL-MYERS COMPANY (US) | 1991-01-08 | — | — | US | disclosed |
| US-4518532-A | ANTITIMOR | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1985-05-21 | — | — | US | disclosed |
| US-4430346-A | N-(4-(3-AMINOPROPYL)AMINOBUTYL)-2-(CS)-7-GUANIDINO-3 -HYDROXYHEPTANAMIDE)-2-HYDROXYETHANAMIDE, ESTERS, AMIDATION ACID CATALYST | BRISTOL-MYERS COMPANY (US) | 1984-02-07 | — | — | US | disclosed |