Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 12/20 | 0.43 |
| ▸ | DRD1 | P21728 | 3/20 | 0.42 |
| ▸ | DRD4 | P21917 | 3/20 | 0.42 |
| ▸ | DRD5 | P21918 | 3/20 | 0.42 |
| ▸ | DRD3 | P35462 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | ACE | P12821 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.39 |
| ▸ | PREP | P48147 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9774220 | 0.89 | ACE (0.47) | HRH1DRD1DRD4DRD5DRD3 | |
| SCHEMBL10511673 | 0.85 | HRH1 (0.42) | HRH1DRD1DRD4DRD5DRD3 | |
| SCHEMBL9774191 | 0.84 | PREP (0.47) | ACEMEN1KMT2ACYP3A4ALOX15 | |
| SCHEMBL9775300 | 0.83 | ACE (0.44) | ACEMEN1KMT2ACYP3A4ALOX15 | |
| SCHEMBL9774133 | 0.82 | PREP (0.47) | ACEMEN1KMT2AFKBP1APREP | |
| SCHEMBL9775269 | 0.82 | ACE (0.46) | ACEMEN1KMT2ACYP3A4ALOX15 | |
| SCHEMBL10514531 | 0.82 | HRH1 (0.45) | HRH1DRD1DRD4DRD5DRD3 | |
| SCHEMBL10515667 | 0.81 | HRH1 (0.42) | HRH1DRD1DRD4DRD5DRD3 | |
| SCHEMBL10513313 | 0.81 | HRH1 (0.44) | HRH1DRD1DRD4DRD5DRD3 | |
| SCHEMBL9775235 | 0.80 | ALDH1A1 (0.50) | ACEMEN1KMT2ACYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4983623-A | Prolyl endopeptidase inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-01-08 | — | — | US | disclosed |