Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 6/20 | 0.48 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.48 |
| ▸ | OPRL1 | P41146 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9543551 | 0.82 | OPRL1 (0.48) | OPRL1ALDH1A1 | |
| SCHEMBL2256110 | 0.82 | EGLN1 (0.53) | PTGDR2EGLN1OPRL1 | |
| SCHEMBL2254486 | 0.81 | EGLN1 (0.52) | PTGDR2EGLN1OPRL1 | |
| SCHEMBL2254620 | 0.81 | EGLN1 (0.52) | EGLN1OPRL1ALDH1A1 | |
| SCHEMBL3711385 | 0.76 | ALDH1A1 (0.47) | PTGDR2ALDH1A1 | |
| SCHEMBL15157179 | 0.76 | TP53 (0.61) | ALDH1A1 | |
| SCHEMBL16812474 | 0.76 | ALDH1A1 (0.49) | PTGDR2EGLN1OPRL1ALDH1A1 | |
| SCHEMBL2255992 | 0.75 | EGLN1 (0.58) | EGLN1OPRL1 | |
| SCHEMBL9544593 | 0.74 | OPRL1 (0.50) | PTGDR2OPRL1ALDH1A1 | |
| SCHEMBL3730104 | 0.74 | OPRL1 (0.58) | PTGDR2EGLN1OPRL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5064852-A | Antidiabetic agents; aldose reductase inhibitors | PFIZER INC. (US) | 1991-11-12 | — | — | US | disclosed |
| US-4960785-A | Indolinone derivatives | PFIZER INC. (US) | 1990-10-02 | — | — | US | disclosed |
| EP-0252713-B1 | INDOLINONE DERIVATIVES | PFIZER INC. (US) | 1990-09-12 | — | — | EP | disclosed |