Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.60 |
| ▸ | HPGD | P15428 | 8/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.60 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | CLK2 | P49760 | 1/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | ATP6V1B2 | P21281 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
| ▸ | EDNRA | P25101 | 1/20 | 0.42 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9775887 | 0.89 | ALDH1A1 (0.62) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL9775878 | 0.88 | KDM4E (0.51) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL9786115 | 0.88 | KDM4E (0.47) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL9786109 | 0.88 | KDM4E (0.47) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL9786133 | 0.88 | KDM4E (0.47) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL9775884 | 0.88 | LMNA (0.52) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL9786246 | 0.88 | KDM4E (0.46) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL9367740 | 0.85 | KDM4E (0.44) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL9786171 | 0.85 | KDM4E (0.44) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL9786184 | 0.85 | KDM4E (0.44) | KDM4EALDH1A1HPGDHSD17B10PMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5004745-A | Benzo[1,8]naphthyridine derivatives, their preparation and the compositions which contain them | LABORATOIRE ROGER BELLON (FR) | 1991-04-02 | — | — | US | disclosed |
| US-4970213-A | Benzo(1,8)naphthyridine derivatives as intermediates | RHONE-POULENC SANTE (FR) | 1990-11-13 | — | — | US | disclosed |