Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.57 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9776687 | 0.98 | PDE5A (0.58) | PDE5ANPY5RNPC1PKMRAB9A | |
| SCHEMBL937937 | 0.86 | NPY5R (0.60) | NPY5RNPC1PKMRAB9AKLF5 | |
| SCHEMBL23577970 | 0.83 | PDE5A (0.59) | PDE5AEGFR | |
| SCHEMBL29909159 | 0.83 | PDE5A (0.59) | PDE5AEGFR | |
| SCHEMBL9776705 | 0.83 | NPC1 (0.59) | NPC1PKMRAB9ANFKB1NFKB2 | |
| Hydrochloric Acid SCHEMBL9776836 | 0.82 | NPC1 (0.61) | NPC1PKMRAB9ANFKB1NFKB2 | |
| Hydrochloric Acid SCHEMBL9776921 | 0.82 | NPC1 (0.61) | NPC1PKMRAB9ANFKB1NFKB2 | |
| SCHEMBL14264133 | 0.79 | ALDH1A1 (0.66) | NPY5RNPC1PKMRAB9AKLF5 | |
| SCHEMBL3117685 | 0.79 | PDE5A (0.66) | PDE5AEGFR | |
| SCHEMBL14264134 | 0.79 | ALDH1A1 (0.71) | NPY5RNPC1PKMRAB9AKLF5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5064833-A | Substituted quinazoline derivatives for use in gastrointestinal diseases | SMITHKLINE BEECHAM INTERCREDIT B.V. (GB) | 1991-11-12 | — | — | US | claimed |
| EP-0322133-B1 | QUINAZOLINE DERIVATIVES | SmithKline Beecham Intercredit B.V. (NL) | 1991-05-22 | — | — | EP | claimed |
| EP-0322133-A1 | Quinazoline derivatives | SmithKline Beecham Intercredit B.V. (NL) | 1989-06-28 | — | — | EP | claimed |