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SCHEMBL9778328

SCHEMBL9778328

COc1ccc(COC2C(=O)C=C(C)N=C2C(O/N=C(\C(=O)O)c2csc(NC(c3ccccc3)(c3ccccc3)c3ccccc3)n2)OC(c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.35

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ GAA P10253 2/20 0.35
▸ MAPT P10636 2/20 0.35
▸ MEN1 O00255 1/20 0.35
▸ KMT2A Q03164 1/20 0.35
▸ NPSR1 Q6W5P4 1/20 0.35
▸ POLB P06746 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9778331 0.90 GAA (0.33) GAAMAPTMEN1KMT2ANPSR1
SCHEMBL9778409 0.79 KMT2A (0.35) MAPTKMT2ANPSR1POLB
SCHEMBL10747586 0.75 MAPT (0.44) GAAMAPTMEN1KMT2ANPSR1
SCHEMBL10804728 0.75 MAPT (0.44) GAAMAPTMEN1KMT2ANPSR1
SCHEMBL9047856 0.73 LMNA (0.32) GAAMAPT
SCHEMBL10447408 0.72 GAA (0.31) GAAMAPTMEN1KMT2ANPSR1
SCHEMBL10436646 0.70 MAPT (0.39) GAAMAPTMEN1KMT2ANPSR1
SCHEMBL10436652 0.70 MAPT (0.39) GAAMAPTMEN1KMT2ANPSR1
SCHEMBL1686923 0.69 MAPT (0.38) GAAMAPTMEN1KMT2ANPSR1
SCHEMBL1686928 0.69 MAPT (0.38) GAAMAPTMEN1KMT2ANPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5075299-A CEPHALOSPORIN COMPOUNDS AND ANTIBACTERIAL AGENTS MEIJI SEIKA KAISHA, LTD. (JP) 1991-12-24 — — US disclosed
EP-0354576-A2 Novel cephalosporin compounds and antibacterial agents MEIJI SEIKA KAISHA LTD. (JP) 1990-02-14 — — EP disclosed
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