SCHEMBL9779028

SCHEMBL9779028

O=Cc1c2ccsc2cc2c1ccc1ccccc12

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ERN1 O75460 1/20 0.42
HPRT1 P00492 4/20 0.41
CYP2A6 P11509 3/20 0.39
CYP1A2 P05177 2/20 0.37
CYP2C9 P11712 2/20 0.37
CYP2C19 P33261 2/20 0.37
MAPT P10636 2/20 0.37
ALDH1A1 P00352 2/20 0.36
HSD17B10 Q99714 2/20 0.36
TSHR P16473 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
TUBB4A P04350 1/20 0.36
TUBB P07437 1/20 0.36
TUBA3C P0DPH7 1/20 0.36
TUBA1B P68363 1/20 0.36
TUBA4A P68366 1/20 0.36
TUBB4B P68371 1/20 0.36
TUBB3 Q13509 1/20 0.36
TUBB2A Q13885 1/20 0.36
TUBB8 Q3ZCM7 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9529453 0.84 TUBB4A (0.45) ERN1CYP2A6CYP1A2CYP2C9CYP2C19
SCHEMBL9779150 0.79 CYP2A6 (0.42) ERN1HPRT1CYP2A6CYP1A2CYP2C9
SCHEMBL10348819 0.79 ERN1 (0.56) ERN1HPRT1CYP2A6CYP1A2CYP2C9
SCHEMBL9537870 0.73 CYP2A6 (0.46) ERN1HPRT1CYP2A6CYP1A2CYP2C9
SCHEMBL547664 0.72 ERN1 (0.49) ERN1HPRT1CYP2A6CYP1A2CYP2C9
SCHEMBL362053 0.72 ALDH1A1 (0.56) HPRT1CYP2A6CYP1A2MAPTALDH1A1
SCHEMBL29808493 0.72 ALDH1A1 (0.56) HPRT1CYP2A6CYP1A2MAPTALDH1A1
SCHEMBL31471980 0.71 HPRT1 (0.58) HPRT1CYP2A6CYP1A2CYP2C9CYP2C19
SCHEMBL12278069 0.71 HPRT1 (0.58) HPRT1CYP2A6CYP1A2CYP2C9CYP2C19
SCHEMBL1487826 0.71 HPRT1 (0.58) HPRT1CYP2A6CYP1A2CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4999369-A Antitumor agents BURROUGHS WELLCOME CO. (US) 1991-03-12 US disclosed
US-4910218-A With a hydroxy containing secondary amine group BURROUGHS WELLCOME CO. (US) 1990-03-20 US disclosed