SCHEMBL9779476

SCHEMBL9779476

Cc1nc(-c2cccc(Cl)c2)cc(-c2cccc(C#N)c2)c1C(=O)NCCN1CCOCC1

nearest known ligand 0.48

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CD274 Q9NZQ7 2/20 0.48
LRRK2 Q5S007 1/20 0.47
ALDH1A1 P00352 3/20 0.46
TSHR P16473 1/20 0.46
HTT P42858 1/20 0.46
USP2 O75604 2/20 0.45
CYP1A2 P05177 2/20 0.45
CYP3A4 P08684 2/20 0.45
CLK4 Q9HAZ1 2/20 0.45
CYP2C19 P33261 2/20 0.45
CYP2D6 P10635 1/20 0.45
MAPK1 P28482 1/20 0.45
HTR1A P08908 1/20 0.43
MAOA P21397 1/20 0.43
MAOB P27338 1/20 0.43
KCNH2 Q12809 1/20 0.43
SCN9A Q15858 1/20 0.43
CYP2C9 P11712 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9779369 0.92 ALDH1A1 (0.51) CD274LRRK2ALDH1A1HTTUSP2
SCHEMBL9779270 0.89 HTT (0.54) CD274ALDH1A1TSHRHTT
SCHEMBL9779267 0.88 CD274 (0.52) CD274LRRK2ALDH1A1TSHRUSP2
Hydrochloric Acid SCHEMBL9779394 0.87 ALDH1A1 (0.51) CD274ALDH1A1HTTUSP2CYP1A2
SCHEMBL9779336 0.80 HPGD (0.59) CD274ALDH1A1TSHRHTTCYP1A2
SCHEMBL9779368 0.80 HPGD (0.54) CD274ALDH1A1HTTUSP2
SCHEMBL9779277 0.80 SCN9A (0.48) CD274LRRK2ALDH1A1USP2CYP1A2
SCHEMBL9779547 0.78 HPGD (0.53) CD274ALDH1A1TSHRHTTUSP2
Hydrochloric Acid SCHEMBL9779451 0.78 HPGD (0.50) CD274ALDH1A1TSHRHTTHTR1A
SCHEMBL9779424 0.78 HPGD (0.52) CD274ALDH1A1TSHRHTTCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5037824-A Cardiotonic, antiischemic agents FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) 1991-08-06 US disclosed