Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.51 |
| ▸ | PLK1 | P53350 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6138736 | 0.86 | HAO1 (0.56) | HAO1PLK1TSHRMMP2MMP9 | |
| SCHEMBL17295068 | 0.86 | HAO1 (0.58) | HAO1PLK1KMT2AALDH1A1MAPT | |
| SCHEMBL5768900 | 0.86 | HAO1 (0.58) | HAO1PLK1KMT2AALDH1A1MAPT | |
| SCHEMBL8535748 | 0.80 | KMT2A (0.63) | KMT2AALDH1A1MAPTHTTLMNA | |
| SCHEMBL7575160 | 0.80 | NR4A2 (0.59) | HAO1PLK1KMT2AALDH1A1MAPT | |
| SCHEMBL2305014 | 0.80 | HSD17B3 (0.60) | KMT2AALDH1A1MAPTHTTLMNA | |
| SCHEMBL461531 | 0.80 | HAO1 (0.51) | HAO1PLK1KMT2AALDH1A1MAPT | |
| SCHEMBL5717808 | 0.80 | KMT2A (0.63) | HAO1PLK1KMT2AALDH1A1LMNA | |
| SCHEMBL27197688 | 0.80 | HAO1 (0.42) | HAO1PLK1KMT2AALDH1A1MAPT | |
| SCHEMBL10691601 | 0.80 | ALDH1A1 (0.43) | KMT2AALDH1A1MAPTHTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4990526-A | Skin disorders, antiallergens, antiinflammatory agents | MERCK FROSST CANADA, INC. (CA) | 1991-02-05 | — | — | US | disclosed |
| EP-0206741-A2 | Leukotriene antagonists | MERCK FROSST CANADA INC. (CA) | 1986-12-30 | — | — | EP | disclosed |