SCHEMBL9780478

SCHEMBL9780478

O=S(=O)(NC1CCC(NS(=O)(=O)c2ccc(Br)cc2)c2ccccc21)c1ccc(Br)cc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 2/20 0.57
HTT P42858 2/20 0.57
USP2 O75604 1/20 0.52
HSP90AA1 P07900 1/20 0.50
ALDH1A1 P00352 2/20 0.49
SMN1; SMN2 Q16637 2/20 0.49
CYP1A2 P05177 1/20 0.49
TSHR P16473 1/20 0.49
NPSR1 Q6W5P4 1/20 0.49
TDP1 Q9NUW8 1/20 0.47
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
MMP1 P03956 1/20 0.46
MMP2 P08253 1/20 0.46
MMP9 P14780 1/20 0.46
MMP8 P22894 1/20 0.46
MMP13 P45452 1/20 0.46
HTR1A P08908 1/20 0.45
HTR7 P34969 1/20 0.45
PDE4A P27815 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1659340 0.77 MAPK1 (0.83) MAPK1HTTHSP90AA1ALDH1A1SMN1; SMN2
SCHEMBL3013547 0.74 MAPK1 (0.90) MAPK1HTTHSP90AA1ALDH1A1SMN1; SMN2
SCHEMBL9577211 0.73 MAPT (0.44) MAPK1HTTUSP2ALDH1A1SMN1; SMN2
SCHEMBL12719599 0.72 MAPK1 (1.00) MAPK1HTTALDH1A1SMN1; SMN2TSHR
SCHEMBL13846055 0.72 MAPK1 (1.00) MAPK1HTTALDH1A1SMN1; SMN2TSHR
SCHEMBL2834532 0.72 MAPK1 (1.00) MAPK1HTTALDH1A1SMN1; SMN2TSHR
SCHEMBL10082160 0.72 MAPK1 (1.00) MAPK1HTTALDH1A1SMN1; SMN2TSHR
SCHEMBL8404960 0.72 ALDH1A1 (0.69) MAPK1HTTUSP2ALDH1A1SMN1; SMN2
SCHEMBL5070747 0.72 PSEN1 (0.78) MAPK1HTTHSP90AA1
SCHEMBL3460292 0.71 PDE4A (0.61) MAPK1HTTUSP2ALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4981890-A POLYHALOAROMATIC AND AROMATIC BIS-SULFONAMIDE ETHYL CORPORATION (US) 1991-01-01 US disclosed